Int J Thyroidol.  2024 Nov;17(2):251-258. 10.11106/ijt.2024.17.2.251.

How to Minimize the Complications of Thyroid Surgery

Affiliations
  • 1Department of Otolaryngology-Head and Neck Surgery, Kosin University College of Medicine, Busan, Korea

Abstract

The main goal of thyroid cancer treatment is to completely remove the lesion and minimize recurrence. However, given the very favorable prognosis and the quality of life following the extended lifespan after surgery, completing the surgery without complications is just as important as the complete removal of the cancer. Preventing surgical complications is very important, and the experience of the thyroid surgeon is the most critical factor. Therefore, overcoming the occurrence of complications is a necessary step that a novice must take to become a competent thyroid surgeon. With this background in mind, the author believes that ‘thyroid surgery is a battle with the laryngeal nerves, parathyroid, and blood vessels.’ This review aims to describe methods to minimize postoperative bleeding and hypoparathyroidism based on the author’s experience.

Keyword

Thyroidectomy; Postoperative hemorrhage; Hypoparathyroidism

Figure

  • Fig. 1 Superficial hemtoma from a branch of the anterior jugular vein. Even if the hematoma enlarges significantly, the swelling typically occurs towards the skin rather than the airway. Additionally, as the hemoglobin from the hematoma diffuses towards the skin surface, it causes severe ecchymosis. Despite the neck swelling, there were no symptoms of respiratory distress.

  • Fig. 2 Laryngoscopic findings in a deep hematoma patient 7 days post-hemorrhage. The findings reveal persistent purple discoloration and edema of the posterior pharyngeal wall, arytenoids, false cords, epiglottis, and vocal cords.

  • Fig. 3 Superficial Hematoma above the strap muscle. The hematoma is situated between the skin flap and the strap muscle. This condition can lead to skin ecchymosis but rarely causes dyspnea, as there is minimal compression of the laryngopharynx or trachea.

  • Fig. 4 Near infrared autofluorescence from parathyroid. The strong intensity of parathyroid autofluorescence enable the surgeon discriminate the parathyroid gland from the thyroid fat, muscle, and trachea.

  • Fig. 5 Parathyroid gland mapping with NIRAF imaging. (A) Left thyroid lobe is mobilized but inferior PG is not yet exposed. At this stage, the NIR light is illuminated on the area where the PG is expected to be located. (B) Early localization (mapping) of the PG still veiled by the fatty connective tissue is possible with the NIRAF imaging. (C) Inferior PG is definitely identified by dissecting the connective tissue based on the image. (D) After exposure, the autofluorescence intensity of the PG becomes slightly stronger.17) PG: parathryoid gland


Reference

References

1. Korea Central Cancer Registry, National Cancer Center. Annual report of cancer statistics in Korea in 2021. Ministry of Health and Welfare;2023.
2. Lang BH, Yih PC, Lo CY. 2012; A review of risk factors and timing for postoperative hematoma after thyroidectomy: is outpatient thyroidectomy really safe? World J Surg. 36(10):2497–502. DOI: 10.1007/s00268-012-1682-1. PMID: 22714575. PMCID: PMC3465547.
3. Shandilya M, Kieran S, Walshe P, Timon C. 2006; Cervical haematoma after thyroid surgery: management and prevention. Ir Med J. 99(9):266–8.
4. Lee HS, Lee BJ, Kim SW, Cha YW, Choi YS, Park YH, et al. 2009; Patterns of post-thyroidectomy hemorrhage. Clin Exp Otorhinolaryngol. 2(2):72–7. DOI: 10.3342/ceo.2009.2.2.72. PMID: 19565031. PMCID: PMC2702735.
5. Savargaonkar AP. 2004; Post-thyroidectomy haematoma causing total airway obstruction-a case report. Indian J Anaesth. 48(6):483–5.
6. Mittendorf EA, McHenry CR. 2004; Complications and sequelae of thyroidectomy and an analysis of surgeon experience and outcome. Surg Technol Int. 12:152–7.
7. Pontin A, Pino A, Caruso E, Pinto G, Melita G, Maria P, et al. 2019; Postoperative bleeding after thyroid surgery: care instructions. Sisli Etfal Hastan Tip Bul. 53(4):329–36. DOI: 10.14744/SEMB.2019.95914. PMID: 32377106. PMCID: PMC7192296.
8. Christou N, Mathonnet M. 2013; Complications after total thyroidectomy. J Visc Surg. 150(4):249–56. DOI: 10.1016/j.jviscsurg.2013.04.003. PMID: 23746996.
9. El Malki HO, Abouqal R. Systematic review and meta-analysis of predictors of post-thyroidectomy hypocalcaemia (Br J Surg 2014; 101: 307-320). Br J Surg 2014. 101(7):883. DOI: 10.1002/bjs.9537. PMID: 24817656.
10. Almquist M, Ivarsson K, Nordenström E, Bergenfelz A. 2018; Mortality in patients with permanent hypoparathyroidism after total thyroidectomy. Br J Surg. 105(10):1313–8. DOI: 10.1002/bjs.10843. PMID: 29663312.
11. Gourgiotis S, Moustafellos P, Dimopoulos N, Papaxoinis G, Baratsis S, Hadjiyannakis E. 2006; Inadvertent parathyroidectomy during thyroid surgery: the incidence of a complication of thyroidectomy. Langenbecks Arch Surg. 391(6):557–60. DOI: 10.1007/s00423-006-0079-8. PMID: 16951969.
12. Paras C, Keller M, White L, Phay J, Mahadevan-Jansen A. 2011; Near-infrared autofluorescence for the detection of parathyroid glands. J Biomed Opt. 16(6):067012. DOI: 10.1117/1.3583571. PMID: 21721833.
13. Kim SW, Song SH, Lee HS, Noh WJ, Oak C, Ahn YC, et al. 2016; Intraoperative real-time localization of normal parathyroid glands with autofluorescence imaging. J Clin Endocrinol Metab. 101(12):4646–52. DOI: 10.1210/jc.2016-2558. PMID: 27648967.
14. Falco J, Dip F, Quadri P, de la Fuente M, Prunello M, Rosenthal RJ. 2017; Increased identification of parathyroid glands using near infrared light during thyroid and parathyroid surgery. Surg Endosc. 31(9):3737–42. DOI: 10.1007/s00464-017-5424-1. PMID: 28364157.
15. De Leeuw F, Breuskin I, Abbaci M, Casiraghi O, Mirghani H, Ben Lakhdar A, et al. 2016; Intraoperative near-infrared imaging for parathyroid gland identification by auto-fluorescence: a feasibility study. World J Surg. 40(9):2131–8. DOI: 10.1007/s00268-016-3571-5. PMID: 27220510.
16. Kim SW, Lee HS, Ahn YC, Park CW, Jeon SW, Kim CH, et al. 2018; Near-infrared autofluorescence image-guided parathyroid gland mapping in thyroidectomy. J Am Coll Surg. 226(2):165–72. DOI: 10.1016/j.jamcollsurg.2017.10.015. PMID: 29122718.
17. Lee KD. 2022; Near infrared autofluoroscence (NIRAF) in thyroid surgery. Int J Thyroidol. 15(2):61–7. DOI: 10.11106/ijt.2022.15.2.61.
18. Kahramangil B, Dip F, Benmiloud F, Falco J, de La Fuente M, Verna S, et al. 2018; Detection of parathyroid autofluorescence using near-infrared imaging: a multicenter analysis of concordance between different surgeons. Ann Surg Oncol. 25:957–62. DOI: 10.1245/s10434-018-6364-2. PMID: 29411199.
19. Han YS, Kim Y, Lee HS, Kim Y, Ahn YC, Lee KD. 2023; Detectable depth of unexposed parathyroid glands using near-infrared autofluorescence imaging in thyroid surgery. Front Endocrinol (Lausanne). 14:1170751. DOI: 10.3389/fendo.2023.1170751. PMID: 37113485. PMCID: PMC10126413.
20. Benmiloud F, Godiris-Petit G, Gras R, Gillot JC, Turrin N, Penaranda G, et al. 2020; Association of autofluorescence-based detection of the parathyroid glands during total thyroidectomy with postoperative hypocalcemia risk: results of the PARAFLUO multicenter randomized clinical trial. JAMA Surg. 155(2):106–12. DOI: 10.1001/jamasurg.2019.4613. PMID: 31693081. PMCID: PMC6865247.
21. Kim DH, Kim SW, Kang P, Choi J, Lee HS, Park SY, et al. 2021; Near-infrared autofluorescence imaging may reduce temporary hypoparathyroidism in patients undergoing total thyroidectomy and central neck dissection. Thyroid. 31(9):1400–8. DOI: 10.1089/thy.2021.0056. PMID: 33906431.
22. Falco J, Dip F, Quadri P, de la Fuente M, Rosenthal R. 2016; Cutting edge in thyroid surgery: autofluorescence of parathyroid glands. J Am Coll Surg. 223(2):374–80. DOI: 10.1016/j.jamcollsurg.2016.04.049. PMID: 27212004.
23. McWade MA, Paras C, White LM, Phay JE, Solorzano CC, Broome JT, et al. 2014; Label-free intraoperative parathyroid localization with near-infrared autofluorescence imaging. J Clin Endocrinol Metab. 99(12):4574–80. DOI: 10.1210/jc.2014-2503. PMID: 25148235. PMCID: PMC4255111.
24. Benmiloud F, Penaranda G, Chiche L, Rebaudet S. 2022; Intraoperative mapping angiograms of the parathyroid glands using indocyanine green during thyroid surgery: results of the fluogreen study. World J Surg. 46(2):416–24. DOI: 10.1007/s00268-021-06353-4. PMID: 34743241.
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