Korean Circ J.  2024 Nov;54(11):764-766. 10.4070/kcj.2024.0219.

Fragile Arteries in Loeys-Dietz Syndrome

• Wang C
• Zhang W
• Wang G
• Zou Z
• Chen M
• Zhang H
• Qin S
• Fan X

• KMID: 2560652
• DOI: http://doi.org/10.4070/kcj.2024.0219

Figure

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  Figure 1 Fragile aortic processes in patients with Loeys-Dietz syndrome.(A) Computed tomography angiography revealed type B aortic dissection and bilateral subclavian artery aneurysms. (B) Three-dimensional reconstruction of the aorta after thoracic endovascular aortic repair and left subclavian artery bypass. (C) The residual dissection of the descending aorta was dilated rapidly, with a maximum diameter of 60 mm. (D) Three-dimensional reconstruction of the aorta after total descending aortic replacement. (E) A proximal new aortic dissection was found in the ascending aorta after total descending aortic replacement. (F) The aorta has been completely replaced with artificial material. No leakage, branches of aortic arch and abdominal aorta were patent.

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  Figure 2 The tears of the proximal new aortic dissection.(A) Computed tomography angiography showed the tears (red arrow) of the dissection were located in the ascending aorta. (B) Three-dimensional reconstruction showing the tears (red region) of an aortic dissection.

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  Figure 3 Computational fluid dynamic after total descending aorta replacement.Computational fluid dynamic was applied to mimic (A) aortic streamline and velocity, (B) pressure, (C) WSS, (D) TAWSS, and (E) OSI.OSI = oscillatory shear index; TAWSS = time-averaged wall shear stress; WSS = wall shear stress.

Reference

1. Loughborough WW, Minhas KS, Rodrigues JCL, et al. Cardiovascular manifestations and complications of Loeys-Dietz syndrome: CT and MR imaging findings. Radiographics. 2018; 38:275–286. PMID: 29320330.