Asian Spine J.  2024 Oct;18(5):639-646. 10.31616/asj.2024.0194.

Effect of cannabis use history on postoperative opioid utilization in lumbar fusion patients: an American retrospective study

• Mirpuri P
• Khalid SI
• King P
• Roy JM
• Elsamadicy A
• Mehta AI
• Adogwa O

• KMID: 2560437
• DOI: http://doi.org/10.31616/asj.2024.0194

Abstract

Study Design: A retrospective cohort study. Purpose: To examine the effect of cannabis use history on postoperative opioid utilization in patients undergoing one- to three-level lumbar fusion for degenerative spine disease. Overview of Literature: Strategies to minimize dosing and chronic opioid use are needed for spine surgery given their widespread prescription for postsurgical pain management.
Methods
In this database study, medical coding was used to identify patients who had undergone one- to three-level lumbar fusions between 2012 and 2021. Propensity score matching was used to create two equal cohorts with respect to cannabis use history. Opioid utilization rates (morphine milligram equivalents [MME]/day) and overuse rates at 6 months post-index procedure were assessed. All pvalues <0.05 were considered statistically significant.
Results
Following examination of 153,500 patient records, 1,216 patients were matched into cannabis user and non-cannabis user cohorts. Cannabis users had lower rates of opioid utilization compared to non-cannabis users as early as 2 months after fusion (47.7% vs. 41.1%, p <0.05), a relationship which persisted at 6 months (46.2% vs. 37.7%, p <0.01). Additionally, cannabis users had lower rates of high-dose opioid utilization (≥100 MME per day) during the initial 14–30 days following surgery (6.91% vs. 3.79%, p <0.05).
Conclusions
Patients with a history of cannabis use were less likely to be using opioids as early as 2 months postoperatively and had lower rates of high-dose opioid utilization in the immediate postoperative period. Physicians operating on these patients should consider their cannabis use patterns to provide appropriate titration of pain medication over time.

Keyword

Cannabis; Lumbar fusion; Opioid; Opioid epidemic; Pain management