Int J Arrhythm.
2024 Sep;25(3):16. 10.1186/s42444-024-00123-8.
Ablation strategy for idiopathic outflow tract premature ventricular complexes: rationale and design of the ABOUT‑PVC study, a prospective multicenter study
- Affiliations
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- 1Division of Cardiology, Department of Internal Medicine, Konkuk Univer‑ sity Medical Center, Konkuk University School of Medicine, Seoul, Republic of Korea.
- 2Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
- 3Division of Cardiology, Department of Internal Medicine, College of Medicine, Seoul St. Mary’s Hospital, The Catholic University of Korea, Seoul, Republic of Korea.
- 4Division of Cardiology, Department of Internal Medicine, Chonnam National University Hospital, Chonnam National University School of Medicine, Gwangju, Republic of Korea
- 5Division of Cardiology, Department of Internal Medicine, Kyung Hee Univer‑ sity Hospital, Kyung Hee University, Seoul, Republic of Korea
- 6Asan Medical Center, Heart Institute, University of Ulsan College of Medicine, Seoul, Republic of Korea
- 7Division of Cardiology, Department of Internal Medicine, Korea University Medical Center, Seoul, Republic of Korea
- 8Division of Cardiology, Department of Internal Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Republic of Korea
- 9Division of Cardiology, Yonsei Cardiovascular Center and Cardiovascular Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea
- 10Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea
- 11Divi‑ sion of Cardiology, Department of Internal Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Republic of Korea.
- KMID: 2559705
- DOI: http://doi.org/10.1186/s42444-024-00123-8
Abstract
- Background
An idiopathic outflow tract premature ventricular complex (OT-PVC) is a common arrhythmia, and the accuracy of site of origin prediction using the 12-lead electrocardiogram (ECG) algorithm is not high. There are no studies about a systematic strategy that can provide practical help to electrophysiologists in OT-PVC mapping and ablation. This study aims to evaluate the efficacy and safety of the proposed ablation protocol and establish an optimal catheter ablation strategy by simultaneously investigating and synthesizing various indicators observed during the mapping procedure.
Methods
and design This study (ABOUT-PVC) was designed as a prospective multicenter study to enroll 210 patients from 11 tertiary university hospitals over an estimated 27 months. Patients with idiopathic OT-PVC requiring catheter ablation will receive the procedure through a proposed ablation strategy and will be followed up for at least 12 months. The primary outcome is the acute procedural success rate. The secondary outcomes are clinical success rate, procedure time, complication rate, symptom relief, and changes in echocardiographic parameters.
Conclusions
The ABOUT-PVC study was designed to investigate the efficacy and safety of the proposed ablation strategy and establish an optimal catheter ablation strategy. We expect this study to overcome the limitations of the ECG prediction algorithms and provide a practical guide to electrophysiologists, increasing the procedure’s success rate and reducing complications and procedure time.
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