Exp Neurobiol.
2024 Aug;33(4):202-214. 10.5607/en24004.
Phosphorylated Tau in the Taste Buds of Alzheimer’s Disease Mouse Models
- Affiliations
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- 1BK21 Graduate Program, Department of Biomedical Sciences, Korea University College of Medicine, Seoul 02841, Korea
- 2Department of Pharmacology, Korea University College of Medicine, Seoul 02841, Korea
- 3Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul 03080, Korea
- 4Convergence Research Center for Dementia, Seoul National University Medical Research Center, Seoul 03080, Korea
- 5Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Korea
- 6School of Biological Sciences, Seoul National University, Seoul 08826, Korea
- 7Sensory Organ Research Institute, Seoul National University Medical Research Center, Seoul 03080, Korea
- KMID: 2559615
- DOI: http://doi.org/10.5607/en24004
Abstract
- Numerous systemic diseases manifest with oral symptoms and signs. The molecular diagnosis of Alzheimer’s disease (AD), the most prevalent neurodegenerative disease worldwide, currently relies on invasive or expensive methods, emphasizing the imperative for easily accessible biomarkers. In this study, we explored the expression patterns of key proteins implicated in AD pathophysiology within the taste buds of mice. We detected the expression of amyloid precursor protein (APP) and tau protein in the taste buds of normal C57BL/6 mice. Phosphorylated tau was predominantly found in type II and III taste cells, while APP was located in type I taste cells. Remarkably, we observed significantly stronger immunoreactivity to phosphorylated tau in the taste buds of aged AD mouse models compared to age-matched controls. These findings underscore the oral expression of biomarkers associated with AD, highlighting the diagnostic potential of the oral cavity for neurodegenerative diseases.
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