Korean J Gastroenterol.  2024 Aug;84(2):90-94. 10.4166/kjg.2024.072.

Intestinal Perforation in a Case of Peripheral T Cell Lymphoma after Initiation of Chemotherapy

• Ponnusamy R
• Dasgupta P
• Pai A

• KMID: 2558898
• DOI: http://doi.org/10.4166/kjg.2024.072

Abstract

Non-Hodgkin’s lymphoma (NHL) is the most common type of Gastrointestinal (GI) lymphoma with known complications such as bleeding, obstruction and perforation. In this article we present a 59-year-old male patient diagnosed with Peripheral T cell Lymphoma – Not Otherwise Specified (PTCL-NOS) with GI involvement was started on chemotherapy. On day 2 post completion of first cycle of chemotherapy, patient had presented to the emergency department with sudden onset abdominal pain and distension. On evaluation, he was diagnosed with multiple perforations in the small bowel. Patient underwent exploration with primary repair of few perforations and ileal resection with double barrel ileostomy. Chemotherapy plays an important role in the management of NHL. One well-known NHL consequence, intestinal perforation, can happen at the time of initial presentation or after starting chemotherapy. Surgeons should be aware of possibility of such complications and high-risk factors for perforation. At present, there is no role for elective surgery in GI lymphoma and is mainly reserved for complications like uncontrolled bleeding, obstruction or perforation.

Keyword

Lymphoma; Chemotherapy; Non-Hodgkin; Complications; T Cell lymphoma

Figure

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  Fig. 1 CECT Abdomen showing heterogenously enhancing retroperitoneal mass (arrow). Multiple hypodense hypo enhancing nodules in spleen. CECT, contrast enhanced computed tomography.

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  Fig. 2 Laparoscopic view of the lymph nodal mass (arrow).

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  Fig. 3 CT Abdomen showing pneumoperitoneum.

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  Fig. 4 Laparoscopic view of small bowel perforation (arrow).

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