Recent Update on PET/CT Radiotracers for Imaging Cerebral Glioma

Kim, Dongwoo; Lee, Suk‑Hyun; Hwang, Hee Sung; Kim, Sun Jung; Yun, Mijin

Nucl Med Mol Imaging. 2024 Aug;58(4):237-245. 10.1007/s13139-024-00847-4.

Recent Update on PET/CT Radiotracers for Imaging Cerebral Glioma

Affiliations

¹Department of Nuclear Medicine, Severance Hospital, Yonsei University College of Medicine, 50‑1 Yonsei‑Ro, Seodaemun‑Gu, Seoul 03722, Republic of Korea
²Department of Radiology, Hallym University Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul 07441, Republic of Korea
³Department of Nuclear Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Republic of Korea
⁴Department of Nuclear Medicine, National Health Insurance Service Ilsan Hospital, Goyang 10444, Republic of Korea

KMID: 2558873
DOI: http://doi.org/10.1007/s13139-024-00847-4

Abstract

Positron emission tomography/computed tomography (PET/CT) has dramatically altered the landscape of noninvasive glioma evaluation, offering complementary insights to those gained through magnetic resonance imaging (MRI). PET/CT scans enable a multifaceted analysis of glioma biology, supporting clinical applications from grading and differential diagnosis to mapping the full extent of tumors and planning subsequent treatments and evaluations. With a broad array of specialized radiotracers, researchers and clinicians can now probe various biological characteristics of gliomas, such as glucose utilization, cellular proliferation, oxygen deficiency, amino acid trafficking, and reactive astrogliosis. This review aims to provide a recent update on the application of versatile PET/CT radiotracers in glioma research and clinical practice.

Keyword

Glioma ; ¹⁸ F-FDG; Amino acid radiotracer; ¹¹ C-acetate; ¹⁸F-FLT; ¹⁸F-FMISO

Recent Update on PET/CT Radiotracers for Imaging Cerebral Glioma

Abstract

Keyword

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