Allergy Asthma Respir Dis.
2024 Jul;12(3):125-133. 10.4168/aard.2024.12.3.125.
The Korean Academy of Asthma Allergy and Clinical Immunology guidelines for sublingual immunotherapy
- Ryu G1
- Jee HM2
- Lee HY3
- Kang SY4
- Kim K5
- Kim JH6
- Park KH7
- Park SY8
- Sung MS9
- Lee Y10
- Yang EA11
- Min JY12
- Ha EK13
- Lee SM4
- Lee YW14
- Chung EH15
- Choi SH16
- Koh YI17
- Kim ST18
- Nahm DH10
- Park JW7
- Shim JY19
- An YM20
- Han MY2
- Choi JH21
- Shin YS
10 - Han DH22
- for the Korean Academy of Asthma Allergy and Clinical Immunology (KAAACI) Allergen Immunotherapy and Allergen Working Group
- Affiliations
-
- 1Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
- 2Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea
- 3Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
- 4Division of Pulmonology and Allergy, Department of Internal Medicine, Gachon University Gil Medical Center, Gachon University College of Medicine, Incheon, Korea
- 5Department of Pediatrics, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea
- 6Department of Pediatrics, Kyung Hee University School of Medicine, Seoul, Korea
- 7Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
- 8Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea
- 9Department of Pediatrics, Soonchunhyang University Gumi Hospital, Gumi, Korea
- 10Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea
- 11Department of Pediatrics, Daejeon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Daejeon, Korea
- 12Department of Otorhinolaryngology-Head & Neck Surgery, Kyung Hee University Hospital, Kyung Hee University College of Medicine, Seoul, Korea
- 13Department of Pediatrics, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea
- 14Division of Allergy & Clinical Immunology, Department of Internal Medicine, Center for Health Policy Research, Catholic Kwandong University College of Medicine, International St. Mary’s Hospital, Incheon, Korea
- 15Department of Pediatrics, Chungnam National University School of Medicine, Daejeon, Korea
- 16Department of Pediatrics, Kyung Hee University Hospital at Gangdong, Seoul, Korea
- 17Department of Allergy and Clinical Immunology, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea
- 18Department of Otolaryngology-Head & Neck Surgery, Gachon University Gil Medical Center, Gachon University College of Medicine, Incheon, Korea
- 19Department of Pediatrics, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea
- 20Jang’s Pediatrics, Seoul, Korea
- 21Department of Pulmonology and Allergy, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Korea
- 22Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University College of Medicine, Seoul, Korea
- KMID: 2558371
- DOI: http://doi.org/10.4168/aard.2024.12.3.125
Abstract
- Allergen immunotherapy (AIT) has been used for over a century and has been demonstrated to be effective in treating patients with various allergic diseases. AIT allergens can be administered through various routes, including subcutaneous, sublingual, intralymphatic, oral, or epicutaneous routes. Sublingual immunotherapy (SLIT) has recently gained clinical interest, and it is considered an alternative treatment for allergic rhinitis (AR) and asthma. This review provides an overview of the current evidence-based studies that address the use of SLIT for treating AR, including (1) mechanisms of action, (2) appropriate patient selection for SLIT, (3) the current available SLIT products in Korea, and (4) updated information on its efficacy and safety. Finally, this guideline aims to provide the clinician with practical considerations for SLIT.
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