J Korean Neurol Assoc.
2024 Aug;42(3):259-261. 10.17340/jkna.2023.0110.
Delayed Post-hypoxic Leukoencephalopathy after Carbon Monoxide Intoxication Improved by High-dose Steroid Treatment
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- 1Department of Neurology, Chungnam National University Hospital, Daejeon, Korea
- KMID: 2558357
- DOI: http://doi.org/10.17340/jkna.2023.0110
Abstract
- Delayed post-hypoxic leukoencephalopathy (DHPL) is a demyelinating syndrome characterized by acute onset of neuropsychiatric symptoms within days to weeks following apparent recovery from coma after a period of prolonged cerebral hypo-oxygenation. The majority of DPHL cases are associated with carbon monoxide intoxication. There is no specific treatment, and the prognosis is usually poor. However, we present a case of DHPL patient with akinetic mutism, parkinsonism, stool and urine incontinence, and severe cognitive impairment improved after treatment with high-dose steroid therapy.
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