Clin Endosc.  2024 Jul;57(4):446-453. 10.5946/ce.2023.193.

Clinical meaning of sarcopenia in patients undergoing endoscopic treatment

• Hisada H
• Tsuji Y
• Kuribara H
• Miyata R
• Oshio K
• Mizutani S
• Nakagawa H
• Cho R
• Sakuma N
• Miura Y
• Mizutani H
• Ohki D
• Yakabi S
• Takahashi Y
• Sakaguchi Y
• Kakushima N
• Yamamichi N
• Fujishiro M

• KMID: 2558098
• DOI: http://doi.org/10.5946/ce.2023.193

Abstract

With increasing global life expectancy, the significance of geriatric assessment parameters has increased. Sarcopenia is a crucial assessment parameter and is defined as the age-related loss of muscle mass and strength. Sarcopenia is widely acknowledged as a risk factor for postoperative complications in diverse advanced malignancies and has a detrimental effect on the long-term prognosis. While most studies have primarily concentrated on the correlation between sarcopenia and advanced cancer, more recent investigations have focused on the relationship between sarcopenia and early-stage cancer. Endoscopic submucosal dissection (ESD), which is less invasive than surgical intervention, is extensively employed in the management of early-stage cancer, although it is associated with complications such as bleeding and perforation. In recent years, several reports have revealed the adverse consequences of sarcopenia in patients with early-stage cancer undergoing ESD. This literature review briefly summarizes the recent studies on the association between sarcopenia and ESD.

Keyword

Aged; Endoscopic submucosal dissection; Neoplasms; Prognosis; Sarcopenia

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