J Korean Med Assoc.  2024 Jul;67(7):467-474. 10.5124/jkma.2024.67.7.467.

Integrated management of multiple drugs for cardiovascular disease in older adults

• Kim SY

• KMID: 2558007
• DOI: http://doi.org/10.5124/jkma.2024.67.7.467

Abstract

Background
Older people have a high frequency of use of medical institutions due to their multiple comorbidities, which increases the frequency of drug-related problems or adverse drug reactions, such as duplicate prescriptions and inappropriate drug use. Polypharmacy in older people increases the risk of side effects and drug-drug interactions, thereby affecting health outcomes and quality of life. Because most elderly person with cardiovascular disease are already taking multiple drugs, the risk is inevitably high. Therefore, there is a need to develop strategies to mitigate the adverse effects of multidrug therapy in older adults with cardiovascular diseases.
Current Concepts
We reviewed the latest relevant guidelines and literature in order to provide practical considerations for appropriate prescriptions for older people with cardiovascular disease, balancing unnecessary or harmful drugs with proven long-term benefits.
Discussion and Conclusion
Continuous dialogue between healthcare providers and patients allows the close monitoring of drug efficacy and the prevention of adverse events. Drug therapy requires individualization as treatment goals vary with advancing age.

Keyword

Polypharmacy; Cardiovascular diseases; Primary prevention; Secondary prevention; 다약제; 심혈관질환; 1차예방; 2차예방