Ann Lab Med.  2024 Jul;44(4):375-377. 10.3343/alm.2023.0474.

A Severe Infection Caused by a White Colony-Producing Strain of Clostridioides difficile RTC41/ST588

• Park SY
• Kim H
• Lee Y

• KMID: 2557939
• DOI: http://doi.org/10.3343/alm.2023.0474

Figure

• 

  Fig. 1 Colonial morphology of Clostridioides difficile HY1126. (A) Flat gray on Brucella blood agar. (B) White colonies on ChromID agar. (C) Fluorescent colonies on CHROM CDIF agar.

• 

  Fig. 2 PCR ribotyping pattern of Clostridioides difficile. Lanes L, ladder; lane 1, RT023; lane 2, RTC41 (HY1126); lane 3, RT027.

Reference

References

1. Guh AY, Mu Y, Winston LG, Johnston H, Olson D, Farley MM, et al. 2020; Trends in U.S. burden of Clostridioides difficile infection and outcomes. N Engl J Med. 382:1320–30. DOI: 10.1056/NEJMoa1910215. PMID: 32242357. PMCID: PMC7861882.

2. Shaw HA, Preston MD, Vendrik KEW, Cairns MD, Browne HP, Stabler RA, et al. 2020; The recent emergence of a highly related virulent Clostridium difficile clade with unique characteristics. Clin Microbiol Infect. 26:492–8. DOI: 10.1016/j.cmi.2019.09.004. PMID: 31525517. PMCID: PMC7167513.

3. Kim MH, Kim YC, Kim JL, Park YS, Kim H. 2022; Description of antibiotic treatment in adults tested for Clostridioides difficile infection: a single-center case-control study. BMC Infect Dis. 22:1–9. DOI: 10.1186/s12879-022-07085-z. PMID: 35093016. PMCID: PMC8801153. PMID: e86375e84c444a2f994e41ad58dbb3d2.

4. Chung HS, Park JS, Shin BM, Yoo HM, Kim H, Cho J, et al. 2022; Nationwide survey for current status of laboratory diagnosis of Clostridioides difficile infection in Korea. J Korean Med Sci. 37:e38. DOI: 10.3346/jkms.2022.37.e38. PMID: 35132844. PMCID: PMC8822111.

5. Shivaperumal N, Knight DR, Imwattana K, Androga GO, Chang BJ, Riley TV. 2022; Esculin hydrolysis negative and TcdA-only producing strains of Clostridium (Clostridioides) difficile from the environment in Western Australia. J Appl Microbiol. 133:1183–96. DOI: 10.1111/jam.15500. PMID: 35184359. PMCID: PMC9544920.

6. Imwattana K, Shivaperumal N, Leepattarakit T, Kiratisin P, Knight DR, Riley TV. 2023; The brief case: a white-colony-producing Clostridioides difficile ribotype 020 strain. J Clin Microbiol. 61:e0089322. DOI: 10.1128/jcm.00893-22. PMID: 37338228. PMCID: PMC10281166.

7. Kirkpatrick ID, Greenberg HM. 2001; Evaluating the CT diagnosis of Clostridium difficile colitis: should CT guide therapy? AJR Am J Roentgenol. 176:635–9. DOI: 10.2214/ajr.176.3.1760635. PMID: 11222194.

8. O'Neill GL, Ogunsola FT, Brazier JS, Duerden BI. 1996; Modification of a PCR ribotyping method for application as a routine typing scheme for Clostridium difficile. Anaerobe. 2:205–9. DOI: 10.1006/anae.1996.0028.

9. Stubbs SL, Brazier JS, O'Neill GL, Duerden BI. 1999; PCR targeted to the 16S-23S rRNA gene intergenic spacer region of Clostridium difficile and construction of a library consisting of 116 different PCR ribotypes. J Clin Microbiol. 37:461–3. DOI: 10.1128/JCM.37.2.461-463.1999. PMID: 9889244. PMCID: PMC84342.

10. Curry SR, Marsh JW, Muto CA, O'Leary MM, Pasculle AW, Harrison LH. 2007; tcdC genotypes associated with severe TcdC truncation in an epidemic clone and other strains of Clostridium difficile. J Clin Microbiol. 45:215–21. DOI: 10.1128/JCM.01599-06. PMID: 17035492. PMCID: PMC1828959.