Immune Netw.
2024 Feb;24(1):e6. 10.4110/in.2024.24.e6.
Innate Type-2 Cytokines: From Immune Regulation to Therapeutic Targets
- Affiliations
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- 1Laboratory of Mucosal Immunology, Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Korea
- 2Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul 03080, Korea
- 3Multitasking Macrophage Research Center, Ewha Womans University, Seoul 03760, Korea
- 4Laboratory of Immune Regulation, Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Korea
- 5Ischemic/Hypoxic Disease Institute, Seoul National University Medical Research Center, Seoul 03080, Korea
- 6Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Korea
- 7Department of Pathology, Seoul National University College of Medicine, Seoul 03080, Korea
- KMID: 2557919
- DOI: http://doi.org/10.4110/in.2024.24.e6
Abstract
- The intricate role of innate type-2 cytokines in immune responses is increasingly acknowledged for its dual nature, encompassing both protective and pathogenic dimensions. Ranging from defense against parasitic infections to contributing to inflammatory diseases like asthma, fibrosis, and obesity, these cytokines intricately engage with various innate immune cells. This review meticulously explores the cellular origins of innate type-2 cytokines and their intricate interactions, shedding light on factors that amplify the innate type-2 response, including TSLP, IL-25, and IL-33. Recent advancements in therapeutic strategies, specifically the utilization of biologics targeting pivotal cytokines (IL-4, IL-5, and IL-13), are discussed, offering insights into both challenges and opportunities. Acknowledging the pivotal role of innate type-2 cytokines in orchestrating immune responses positions them as promising therapeutic targets. The evolving landscape of research and development in this field not only propels immunological knowledge forward but also holds the promise of more effective treatments in the future.
