Nat Prod Sci.
2024 Jun;30(2):130-134. 10.20307/nps.2024.30.2.130.
Indole Derivatives and a Diketopiperazine from Chromobacterium violaceum
- Affiliations
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- 1Department of Biopharmaceutical Convergence, Sungkyunkwan University, Suwon 16419, Republic of Korea
- 2School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea
- KMID: 2557840
- DOI: http://doi.org/10.20307/nps.2024.30.2.130
Abstract
- Three indole derivatives (1–3) and a diketopiperazine (4) were isolated from the ethyl acetate extract of Chromobacterium violaceum. Their structures were elucidated based on the analysis of NMR and HR-MS data and by comparing those in the previous literature. The antibacterial activities of the isolated compounds were evaluated against Gram-positive bacteria, including human pathogenic methicillin-resistant Staphylococcus aureus (MRSA), Lacticaseibacillus paracasei subsp. paracasei, and Brevibacterium epidermidis. Compound 1 exhibited moderate antibacterial activity against all the three strains with MIC values ranging from 8.58 to 34.3 μg/mL.
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