Nat Prod Sci.  2024 Jun;30(2):72-79. 10.20307/nps.2024.30.2.72.

A New Vomifoliol Derivative and Flavonoids from the Aerial Parts of Orthosiphon aristatus

• Kim HJ
• Shin KJ
• Htwe KM
• Yoon KD

• KMID: 2557834
• DOI: http://doi.org/10.20307/nps.2024.30.2.72

Abstract

Orthosiphon aristatus (Lamiaceae) is a perennial herbaceous plant native to tropical Southeast Asia countries. The chemical investigation on this plant led to the isolation and structure elucidation of a new vomifoliol derivative (1) along with eighteen known phenolic compounds [cystosiphonin (2), 5,7,8-trimethoxyflavanone (3), scutellarein-7,4′-methylether (4), eupatorin (5), 5,6,7,8,4′-pentamethoxyflavone (6), 5,6,7,4′-tetramethylscutellarein (7), 5,6,7,8,3′,4′-hexamethoxyflavone (8), 6-hydroxy-5,7,4′-trimethoxyflavone (9), 6,7,8,3′,4′-pentamethoxyflavone (10), 5,6,3′-trihydroxy-7,4′-dimethoxyflavone (11), 5,6-dihydroxy-7,3′,4′-trimethoxy flavone (12), 4′-hydroxy-5,6,7,3′-tetramethoxyflavone (13), 2′-hydroxy-3,4,4′,5′,6′-pentamethoxy-chalcone (14), isoquercetin (15), quercetin 3-O-α-L-arabinopyranosyl (1→6)-β-Dglucopyranoside (16), caffeic acid (17), rosmarinic acid (18), and (6S,9R)-roseoside (19)]. The structures of isolates were confirmed via spectroscopic data such as one- and two-dimensional nuclear magnetic resonance, circular dichroism, mass, ultraviolet and optical rotation.

Keyword

Orthosiphon aristatus; Lamiaceae; Vomifoliol derivative; Phenolic compounds