J Periodontal Implant Sci.
2023 Jun;53(3):218-232. 10.5051/jpis.2300660033.
Sinus augmentation with poly(ε) caprolactone-β tricalcium phosphate scaffolds, mesenchymal stem cells and platelet rich plasma for one-stage dental implantation in minipigs
- Affiliations
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- 1Department of Oral & Maxillofacial Surgery, School of Dentistry, Seoul National University, Seoul, Korea
- 2Dental Life Science Research Institute, Innovation Research & Support Center for Dental Science, Seoul National University Dental Hospital, Seoul, Korea Dental Life Science Research Institute, Innovation Research & Support Center for Dental Science, Seoul National University Dental Hospital, Seoul, Korea
- 3Department of Chemical and Biochemical Engineering, College of Engineering, Dongkuk University, Seoul, KoreaDepartment of Chemical and Biochemical Engineering, College of Engineering, Dongkuk University, Seoul, Korea
- 4Department of Oral & Maxillofacial Surgery, Section of Dentistry, Seoul National University Bundang Hospital, Seongnam, Korea
- 5Oral Oncology Clinic, National Cancer Center, Ilsan, KoreaOral Oncology Clinic, National Cancer Center, Ilsan, Korea
- 6Department of Oral & Maxillofacial Surgery, Seoul National University Gwanak Dental Hospital, Seoul, Koreav
- KMID: 2557203
- DOI: http://doi.org/10.5051/jpis.2300660033
Abstract
- Purpose
This study evaluated the efficacy of a tube-shaped poly(ε) caprolactone - β tricalcium phosphate (PCL-TCP) scaffold with the incorporation of human umbilical cord-derived mesenchymal stem cells (hUCMSCs) and platelet-rich plasma (PRP) for bone regeneration in the procedure of single-stage sinus augmentation and dental implantation in minipigs.
Methods
Implants were placed in the bilateral sides of the maxillary sinuses of 5 minipigs and allocated to a PCL-TCP+hUCMSCs+PRP group (n=5), a PCL-TCP+PRP group (n=5), and a PCL-TCP-only group (n=6). After 12 weeks, bone regeneration was evaluated with soft X-rays, micro-computed tomography, fluorescence microscopy, and histomorphometric analysis.
Results
Four implants failed (2 each in the PCL-TCP+hUCMSCs+PRP and PCLTCP+hUCMSC groups). An analysis of the grayscale levels and bone-implant contact ratio showed significantly higher mean values in the PCL-TCP+hUCMSCs+PRP than in the PCL-TCP group (P=0.045 and P=0.016, respectively). In fluoromicroscopic images, new bone formation around the outer surfaces of the scaffolds was observed in the PCLTCP+hUCMSCs+PRP group, suggesting a tenting effect of the specially designed scaffolds. Bone regeneration at the scaffold-implant interfaces was observed in all 3 groups.
Conclusions
Using a tube-shaped, honeycombed PCL-TCP scaffold with hUCMSCs and PRP may serve to enhance bone formation and dental implants’ osseointegration in the procedure of simultaneous sinus lifting and dental implantation.v
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