J Wound Manag Res.  2024 Jun;20(2):122-127. 10.22467/jwmr.2024.02901.

Evaluation of Silicone-Based Gel for the Treatment of Hypertrophic Scarring in Rat Models

• Yim SJ
• Nam DY
• Choi DH
• Woo J
• Kim Y
• Chae J
• Lee YS
• Jung JY

• KMID: 2556998
• DOI: http://doi.org/10.22467/jwmr.2024.02901

Abstract

Background
Hypertrophic scarring represents an aberrant response to wounds in certain individuals, manifesting with symptoms such as itching, tenderness, pain, and pigmentation. This study aimed to investigate the impact of a silicone-based gel on the healing of hypertrophic scars, particularly those originating from deep tissue wounds.
Methods
A rat model of wound healing and scarring was established, and 12 rats were randomly assigned to three groups: Dermatix Ultra group, SFG-100 silicone-gel group, and non-treated group. Rats in the treated groups (Dermatix Ultra and SFG-100 silicone-gel) received twice-daily applications for 8 weeks. Histologic analysis, including biopsy, was conducted to evaluate the scar elevation index, epidermis thickness, and the number of granulation veins.
Results
Overall, both the Dermatix Ultra and SFG-100 silicone-gel groups exhibited improvements in hypertrophic scar healing, accompanied by a significant reduction in skin pigmentation. Histopathologically, scars in both treated groups displayed a notable decrease in scar elevation index, epithelial thickness, and collagen disorganization compared to the non-treated group. However, no significant difference was observed between the Dermatix Ultra and SFG-100 silicone-gel groups.
Conclusion
The results suggest that SFG-100 silicone-gel is an effective therapeutic agent for hypertrophic scars. Further research is warranted to elucidate the mechanisms underlying its efficacy and to optimize its application for clinical use.

Keyword

Hypertrophic scar; Animal model; Silicone gels; Histology