Tuberc Respir Dis.  2024 Jul;87(3):252-260. 10.4046/trd.2024.0001.

What Single Cell RNA Sequencing Has Taught Us about Chronic Obstructive Pulmonary Disease

• Sin DD

• KMID: 2556824
• DOI: http://doi.org/10.4046/trd.2024.0001

Abstract

Chronic obstructive pulmonary disease (COPD) affects close to 400 million people worldwide and is the 3rd leading cause of mortality. It is a heterogeneous disorder with multiple endophenotypes, each driven by specific molecular networks and processes. Therapeutic discovery in COPD has lagged behind other disease areas owing to a lack of understanding of its pathobiology and scarcity of biomarkers to guide therapies. Single cell RNA sequencing (scRNA-seq) is a powerful new tool to identify important cellular and molecular networks that play a crucial role in disease pathogenesis. This paper provides an overview of the scRNA-seq technology and its application in COPD and the lessons learned to date from scRNA-seq experiments in COPD.

Keyword

Chronic Obstructive Pulmonary Disease; Sequencing; Single Cell; Technology