Endocrinol Metab.  2024 Jun;39(3):534-536. 10.3803/EnM.2024.2035.

Potential of Calcilytics as a Novel Treatment for Post-Surgical Hypoparathyroidism

Affiliations
  • 1Division of Endocrinology and Metabolism, Department of Internal Medicine, Dongguk University Ilsan Hospital, Goyang, Korea


Figure

  • Fig. 1. Hematoxylin and eosin staining in autotransplanted parathyroid tissue in the sternocleidomastoid muscle. The data are presented as means±standard error of the mean. aP<0.05 vs. the vehicle group.

  • Fig. 2. Immunohistochemical staining for parathyroid hormone (PTH), vascular endothelial growth factor A (VEGFA), and cluster of differentiation 31 (CD31) in autotransplanted parathyroid tissue in the sternocleidomastoid muscle. The data are presented as means±standard error of the mean. aP<0.05, bP<0.01, cP<0.001 vs. the vehicle group.


Reference

1. Mannstadt M, Bilezikian JP, Thakker RV, Hannan FM, Clarke BL, Rejnmark L, et al. Hypoparathyroidism. Nat Rev Dis Primers. 2017; 3:17055.
Article
2. Lorente-Poch L, Sancho JJ, Munoz-Nova JL, Sanchez-Velazquez P, Sitges-Serra A. Defining the syndromes of parathyroid failure after total thyroidectomy. Gland Surg. 2015; 4:82–90.
3. Bilezikian JP, Brandi ML, Cusano NE, Mannstadt M, Rejnmark L, Rizzoli R, et al. Management of hypoparathyroidism: present and future. J Clin Endocrinol Metab. 2016; 101:2313–24.
Article
4. Rejnmark L. Treatment of hypoparathyroidism by re-establishing the effects of parathyroid hormone. Endocrinol Metab (Seoul). 2024; 39:262–6.
Article
5. Widler L. Calcilytics: antagonists of the calcium-sensing receptor for the treatment of osteoporosis. Future Med Chem. 2011; 3:535–47.
Article
6. Gafni RI, Hartley IR, Roszko KL, Nemeth EF, Pozo KA, Lombardi E, et al. Efficacy and safety of encaleret in autosomal dominant hypocalcemia type 1. N Engl J Med. 2023; 389:1245–7.
Article
7. Lim YS, You BH, Kim HB, Lim SH, Song JG, Bae MG, et al. A new therapeutic approach using a calcilytic (AXT914) for postsurgical hypoparathyroidism in female rats. Endocrinology. 2020; 161:bqaa145.
Article
8. Carter WB, Uy K, Ward MD, Hoying JB. Parathyroid-induced angiogenesis is VEGF-dependent. Surgery. 2000; 128:458–64.
Article
9. Cusano NE, Rubin MR, Zhang C, Anderson L, Levy E, Costa AG, et al. Parathyroid hormone 1-84 alters circulating vascular endothelial growth factor levels in hypoparathyroidism. J Clin Endocrinol Metab. 2014; 99:E2025–8.
Article
10. Molostvov G, James S, Fletcher S, Bennett J, Lehnert H, Bland R, et al. Extracellular calcium-sensing receptor is functionally expressed in human artery. Am J Physiol Renal Physiol. 2007; 293:F946–55.
Article
Full Text Links
  • ENM
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr