Ann Optom Contact Lens.  2024 Jun;23(2):58-63. 10.52725/aocl.2024.23.2.58.

The Correlation between MMP-9 Point-of-Care Assay and Clinical Symptoms and Signs of Dry Eye Disease

• Han Sy
• So Hr
• Lee Sh
• Baek Jw
• Ra H
• Kang Ny
• Kim Ec

• KMID: 2556625
• DOI: http://doi.org/10.52725/aocl.2024.23.2.58

Abstract

Purpose
To evaluate the correlation between matrix metalloproteinase-9 (MMP-9) point-of-assay and clinical symptoms and signs of dry eye disease.
Methods
We performed a retrospective study for patients diagnosed with dry eye. MMP-9 (InflammaDry) was performed on 235 patients. Patients were assessed using Schirmer test, corneal staining score, tear film breakup time (TBUT) and the Ocular Surface Disease Index (OSDI).
Results
The score of Schirmer test was lower significantly in MMP-9 positive group than in MMP-9 negative group (for each 4.21 ± 5.80 mm, 5.96 ± 8.14 mm; p = 0.035). TBUT was shorter significantly in MMP-9 positive group than in MMP-9 negative group (for each 5.46 ± 4.06 s, 8.27 ± 4.75 s; p = 0.0008). The ratio of positive corneal stain (for each 83%, 31%) and OSDI even or greater than 13 (for each 80%, 75%) was significantly higher in MMP-9 positive group than in MMP-9 negative group (p = 0.00001, p = 0.0044). The value of MMP-9 point-of-care assay showed showed the negative correlation with Schirmer test (Rs = 0.383, p < 0.001), and TBUT (Rs = 0.310, p < 0.05), and showed the positive correlation with corneal staining score (Rs = 0.527, p < 0.001), OSDI (Rs = 0.510, p < 0.001).
Conclusions
MMP-9 point-of-assay accords with clinical symptoms and signs of Dry eye disease, and may be helpful in diagnosing Dry eye disease.

Keyword

Biomarker; Dry eye disease; Matrix metalloproteinase