Tissue Eng Regen Med.
2024 Jun;21(4):557-569. 10.1007/s13770-024-00626-4.
Effect of Gelatin Content on Degradation Behavior of PLLA/ Gelatin Hybrid Membranes
- Affiliations
-
- 1Department of Biomedical Engineering, Daelim University, 29 Imgok-ro, Dongan-gu, Anyang 13916, South Korea
- 2Department of R&D Center, Renewmedical Co., Ltd., 28-7 Jeongju-ro, Bucheon 14532, South Korea
- 3Department of Materials Science and Engineering, Incheon National University, 119 Academy-ro, Yeonsu-gu, Incheon 22012, South Korea
- 4Department of Materials Science and Engineering, Korea Aviation University, 76 Hanggongdaehak-ro, Dukyang-gu, Goyang 10540, South Korea
- 5Department of R&D Center, Hass Co., Ltd, 60 Haan-ro, Gwangmyeong 14322, South Korea
- KMID: 2556265
- DOI: http://doi.org/10.1007/s13770-024-00626-4
Abstract
- BACKGROUND
Poly(L-lactic acid) (PLLA) is a biodegradable polymer (BP) that replaces conventional petroleumbased polymers. The hydrophobicity of biodegradable PLLA periodontal barrier membrane in wet state can be solved by alloying it with natural polymers. Alloying PLLA with gelatin imparts wet mechanical properties, hydrophilicity, shrinkage, degradability and biocompatibility to the polymeric matrix.
METHODS
To investigate membrane performance in the wet state, PLLA/gelatin membranes were synthesized by varying the gelatin concentration from 0 to 80 wt%. The membrane was prepared by electrospinning.
RESULTS
At the macroscopic scale, PLLA containing gelatin can tune the wet mechanical properties, hydrophilicity, water uptake capacity (WUC), degradability and biocompatibility of PLLA/gelatin membranes. As the gelatin content increased from 0 to 80 wt%, the dry tensile strength of the membranes increased from 6.4 to 38.9 MPa and the dry strain at break decreased from 1.7 to 0.19. PLLA/gelatin membranes with a gelatin content exceeding 40% showed excellent biocompatibility and hydrophilicity. However, dimensional change (37.5% after 7 days of soaking), poor tensile stress in wet state (3.48 MPa) and rapid degradation rate (73.7%) were observed. The highest WUC, hydrophilicity, porosity, suitable mechanical properties and biocompatibility were observed for the PLLA/40% gelatin membrane.
CONCLUSION
PLLA/gelatin membranes with gelatin content less than 40% are suitable as barrier membranes for absorbable periodontal tissue regeneration due to their tunable wet mechanical properties, degradability, biocompatibility and lack of dimensional changes.
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