Clin Exp Reprod Med.  2024 Jun;51(2):91-101. 10.5653/cerm.2023.06303.

Genomic aspects in reproductive medicine

• Go M
• Shim SH

• KMID: 2556169
• DOI: http://doi.org/10.5653/cerm.2023.06303

Abstract

Infertility is a complex disease characterized by extreme genetic heterogeneity, compounded by various environmental factors. While there are exceptions, individual genetic and genomic variations related to infertility are typically rare, often family-specific, and may serve as susceptibility factors rather than direct causes of the disease. Consequently, identifying the cause of infertility and developing prevention and treatment strategies based on these factors remain challenging tasks, even in the modern genomic era. In this review, we first examine the genetic and genomic variations associated with infertility, and subsequently summarize the concepts and methods of preimplantation genetic testing in light of advances in genome analysis technology.

Keyword

Genetic variation; High-throughput nucleotide sequencing; Infertility; Preimplantation diagnosis; Reproductive medicine