Clin Endosc.  2024 May;57(3):342-349. 10.5946/ce.2023.130.

Clinical outcomes of nonvariceal upper gastrointestinal bleeding in nonagenarians and octogenarians: a comparative nationwide analysis

• Elfert K
• Love J
• Elromisy E
• Jaber F
• Nayudu S
• Ho S
• Kahaleh M

• KMID: 2555896
• DOI: http://doi.org/10.5946/ce.2023.130

Abstract

Background/Aims
Nonagenarians will purportedly account for 10% of the United States population by 2050. However, no studies have assessed the outcomes of nonvariceal upper gastrointestinal bleeding (NVUGIB) in this age group.
Methods
The National Inpatient Sample database between 2016 and 2020 was used to compare the clinical outcomes of NVUGIB in nonagenarians and octogenarians and evaluate predictors of mortality and the use of esophagogastroduodenoscopy (EGD).
Results
Nonagenarians had higher in-hospital mortality than that of octogenarians (4% vs. 3%, p<0.001). EGD utilization (30% vs. 48%, p<0.001) and blood transfusion (27% vs. 40%, p<0.001) was significantly lower in nonagenarians. Multivariate logistic regression analysis revealed that nonagenarians with NVUGIB had higher odds of mortality (odds ratio [OR], 1.5; 95% confidence interval [CI], 1.3–1.7) and lower odds of EGD utilization (OR, 0.86; 95% CI, 0.83–0.89) than those of octogenarians.
Conclusions
Nonagenarians admitted with NVUGIB have a higher mortality risk than that of octogenarians. EGD is used significantly in managing NVUGIB among nonagenarians; however, its utilization is comparatively lower than in octogenarians. More studies are needed to assess predictors of poor outcomes and the indications of EGD in this growing population.

Keyword

Esophagogastroduodenoscopy; Gastrointestinal hemorrhage; Nonagenarians; Nonvariceal bleeding; Octogenarians

Figure

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  Fig. 1. Predictors of esophagogastroduodenoscopy utilization in patients ≥80 years with nonvariceal upper gastrointestinal bleeding.

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  Fig. 2. Predictors of mortality in patients ≥80 years with nonvariceal upper gastrointestinal bleeding who had undergone esophagogastroduodenoscopy.

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