Korean J Gastroenterol.  2024 Apr;83(4):172-175. 10.4166/kjg.2024.025.

A Case of Synchronous Primary Gastric and Duodenal Mucosa-Associated Lymphoid Tissue Lymphoma in Remission after Helicobacter pylori Eradication

• Kim SH

• KMID: 2555652
• DOI: http://doi.org/10.4166/kjg.2024.025

Figure

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  Fig. 1 Gastric (A) and duodenal (B) MALT lymphoma lesions seen on gastroduodenoscopy. Multiple erosions and edematous swelling of the mucosa are observed. MALT, mucosa-associated lymphoid tissue.

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  Fig. 2 Dense lymphocytic infiltrate with multiple lymphoid follicles in the submucosal layer of the duodenum (hemotoxylin & eosin [H&E], x100).

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  Fig. 3 Immunohistochemical stains of the duodenal MALT lymphoma. CD20 was positive with Ki-67 positive in 5% of cells. MALT, mucosa-associated lymphoid tissue (all four slides, x100).

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  Fig. 4 Images of gastroduodenoscopy 3 months after Helicobacter pylori eradication (A, stomach: B, duodenum). The target lesions, which showed moderate to severe reddish, edematous erosions in the previous endoscopy, have changed dramatically, and the mucosa is less swollen.

Reference

1. Isaacson P, Wright DH. 1984; Extranodal malignant lymphoma arising from mucosa-associated lymphoid tissue. Cancer. 53:2515–2524. DOI: 10.1002/1097-0142(19840601)53:11<2515::AID-CNCR2820531125>3.0.CO;2-C. PMID: 6424928.

2. Parsonnet J, Hansen S, Rodriguez L, et al. 1994; Helicobacter pylori infection and gastric lymphoma. N Engl J Med. 330:1267–1271. DOI: 10.1056/NEJM199405053301803. PMID: 8145781.

3. Montalban C, Manzanal A, Boixeda D, Redondo C, Bellas C. 1995; Treatment of low-grade gastric MALT lymphoma with Helicobacter pylori eradication. Lancet. 345:798–799. DOI: 10.1016/S0140-6736(95)90679-7. PMID: 7891510.

4. Bayerdörffer E, Neubauer A, Rudolph B, et al. 1995; Regression of primary gastric lymphoma of mucosa-associated lymphoid tissue type after cure of Helicobacter pylori infection. MALT Lymphoma Study Group. Lancet. 345:1591–1594. DOI: 10.1016/S0140-6736(95)90113-2. PMID: 7783535.

5. Carman R, Snyder J, Davidson M. 2011; Primary mucosa-associated lymphoid tumor lymphoma of the duodenum: a rare presentation of non-Hodgkin's lymphoma. J Clin Oncol. 29:e226–229. DOI: 10.1200/JCO.2010.31.9525. PMID: 21205760.

6. Toshima M, Aikawa K, Soga K, Shibasaki K, Yoshida K, Emura I. 1999; Primary duodenal MALT lymphoma. Intern Med. 38:957–961. DOI: 10.2169/internalmedicine.38.957. PMID: 10628934.

7. Xiang Z, Onoda N, Ohira M, et al. 2004; Mucosa-associated lymphoid tissue lymphoma of the duodenum: report of a case resistant to Helicobacter pylori eradication. Hepatogastroenterology. 51:732–735.

8. Nagashima R, Takeda H, Maeda K, Ohno S, Takahashi T. 1996; Regression of duodenal mucosa-associated lymphoid tissue lymphoma after eradication of Helicobacter pylori. Gastroenterology. 111:1674–1678. DOI: 10.1016/S0016-5085(96)70032-X. PMID: 8942749.

9. Lepicard A, Lamarque D, Lévy M, et al. 2000; Duodenal mucosa-associated lymphoid tissue lymphoma: treatment with oral cyclophosphamide. Am J Gastroenterol. 95:536–539. DOI: 10.1111/j.1572-0241.2000.t01-1-01781.x. PMID: 10685764.

10. Kim JS, Jung HC, Shin KH, Song IS, Kim CW, Kim CY. 1999; Eradication of Helicobacter pylori infection did not lead to cure of duodenal mucosa-associated lymphoid tissue lymphoma. Scand J Gastroenterol. 34:215–218. DOI: 10.1080/00365529950173122. PMID: 10192204.

11. Na HK, Won SH, Ahn JY, et al. 2021; Clinical course of duodenal mucosa-associated lymphoid tissue lymphoma: Comparison with gastric mucosa-associated lymphoid tissue lymphoma. J Gastroenterol Hepatol. 36:406–412. DOI: 10.1111/jgh.15157. PMID: 32573049.