Korean Circ J.  2024 Apr;54(4):187-188. 10.4070/kcj.2024.0067.

Pleiotropic Effect of Dronedarone Beyond Antiarrhythmic Agent: Reduction of Hypertrophy

• Cha JJ

• KMID: 2555530
• DOI: http://doi.org/10.4070/kcj.2024.0067

Reference

1. Kim D, Yang PS, Joung B. Optimal rhythm control strategy in patients with atrial fibrillation. Korean Circ J. 2022; 52:496–512. PMID: 35790494.

2. Joglar JA, Chung MK, Armbruster AL, et al. 2023 ACC/AHA/ACCP/HRS Guideline for the Diagnosis and Management of Atrial Fibrillation: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2024; 149:e1–e156. PMID: 38033089.

3. Hohnloser SH, Crijns HJ, van Eickels M, et al. ATHENA Investigators. Effect of dronedarone on cardiovascular events in atrial fibrillation. N Engl J Med. 2009; 360:668–678. PMID: 19213680.

4. Rosa GM, Bianco D, Parodi A, et al. Pharmacokinetic and pharmacodynamic profile of dronedarone, a new antiarrhythmic agent for the treatment of atrial fibrillation. Expert Opin Drug Metab Toxicol. 2014; 10:1751–1764. PMID: 25349898.

5. Iram F, Ali S, Ahmad A, Khan SA, Husain A. A review on dronedarone: Pharmacological, pharmacodynamic and pharmacokinetic profile. J Acute Dis. 2016; 5:102–108.

6. Heusch G, Schulz R. Pleiotropic effects of dronedarone on ischemia/reperfusion injury in heart and brain. Cardiovasc Drugs Ther. 2012; 26:257–263. PMID: 22366819.

7. Quintana-Villamandos B, Gomez de Diego JJ, Delgado-Martos MJ, et al. Dronedarone produces early regression of myocardial remodelling in structural heart disease. PLoS One. 2017; 12:e0188442. PMID: 29161309.

8. Chen C, Hu S, Hu HJ, et al. Dronedarone attenuates AngII-induced myocardial hypertrophy through regulating SIRT1/FOXO3/PKIA axis. Korean Circ J. 2024; 54:172–186.

9. Sotomayor-Flores C, Rivera-Mejías P, Vásquez-Trincado C, et al. Angiotensin-(1-9) prevents cardiomyocyte hypertrophy by controlling mitochondrial dynamics via miR-129-3p/PKIA pathway. Cell Death Differ. 2020; 27:2586–2604. PMID: 32152556.

10. Pazó-Sayós L, González MC, Quintana-Villamandos B. Inhibition of the NFATc4/ERK/AKT pathway and improvement of thiol-specific oxidative stress by dronedarone possibly secondary to the reduction of blood pressure in an animal model of ventricular hypertrophy. Front Physiol. 2020; 11:967. PMID: 32982770.