Nucl Med Mol Imaging.  2024 Apr;58(2):86-91. 10.1007/s13139-023-00828-z.

Extrahepatic ⁹⁰Y Complication; Gastric Ulcer Secondary to  ⁹⁰Y Therapy for Liver Metastasis Despite Negative Preprocedural Imaging

• Shea C
• Lamberg H
• Turk S
• Sanogo M
• Turgeon D
• Nojkov B
• Frey K
• Raffel D

• KMID: 2555458
• DOI: http://doi.org/10.1007/s13139-023-00828-z

Abstract

Transarterial radioembolization using yttrium-90 (⁹⁰Y) therapy has become a standard modality of treatment for primary and metastatic liver malignancies due to its high efficacy rate and relatively low risk of adverse effects compared to other forms of locoregional and systemic therapies. Non-target distribution of radio embolic beads and adjacent structure radiation are the two most common adverse effects. However, these are rarely encountered due to thorough imaging and mapping studies prior to ⁹⁰Y therapy. We present the case of a 66-year-old male who developed a radiation-induced gastric ulcer following ⁹⁰Y therapy with negative pre-procedural imaging and mapping who was retrospectively found to have an accessory artery from the left hepatic artery to the gastric antrum.

Keyword

⁹⁰Y TheraSphere; Transarterial radioembolization (TARE); Radiation ulcer; Non-target distribution; Preprocedural imaging