Biomol Ther.
2024 Mar;32(2):231-239. 10.4062/biomolther.2023.103.
Methylanthranilate, a Food Fragrance Attenuates Skin Pigmentation through Downregulation of Melanogenic Enzymes by cAMP Suppression
- Affiliations
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- 1College of Pharmacy, Ewha Womans University, Seoul 03760, Republic of Korea
- 2Department of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Republic of Korea
- KMID: 2553506
- DOI: http://doi.org/10.4062/biomolther.2023.103
Abstract
- Methyl anthranilate (MA) is a botanical fragrance used in food flavoring with unexplored potential in anti-pigment cosmetics. MA dose-dependently reduced melanin content without affecting cell viability, inhibited dendrite elongation and melanosome transfer in the co-culture system of human melanoma cells (MNT-1) and human keratinocyte cell line (HaCaT), and downregulated melanogenic genes, including tyrosinase, tyrosinase-related protein 1 and 2 (TRP-1, TRP-2). Additionally, MA decreased cyclic adenosine monophosphate (cAMP) production and exhibited a significant anti-pigmentary effect in Melanoderm™. These results suggest that MA is a promising anti-pigmentary agent for replacing or complementing existing anti-pigmentary cosmetics.
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