J Korean Med Assoc.  2024 Feb;67(2):96-102. 10.5124/jkma.2024.67.2.96.

Current advances in pharmacotherapy for schizophrenia

• Kim S
• Kim E

• KMID: 2552008
• DOI: http://doi.org/10.5124/jkma.2024.67.2.96

Abstract

Background
Schizophrenia is a complex psychiatric disorder characterized by hallucinations, delusions, and cognitive deficits, often leading to functional decline. Pharmacotherapy has long played a central role in schizophrenia management with our evolving understanding shaping the treatment.
Current Concepts
Antipsychotic agents are the mainstay of the pharmacological treatment of schizophrenia. Although second-generation antipsychotics (atypical) reduce extrapyramidal side effects, they give rise to metabolic concerns. Personalized treatment, guided by the response and side effects of the patient, determines suitable medications and dosages. Long-acting injectable antipsychotics have enhanced medication adherence, and the consideration of clozapine is warranted for treatment-resistant cases. In addition, potential combination therapies with other psychotropic medications could be explored to address specific symptoms or comorbidities.
Discussion and Conclusion
Antipsychotics are pivotal in acute intervention and schizophrenia treatment maintenance. Individualized plans, accounting for drug response, side effects, and adherence, are essential when selecting specific antipsychotic agents. Long-acting injectables and clozapine with combination therapies for treatment resistance offer effective and tolerable management. Ongoing studies and novel antipsychotic development hold promise for improving schizophrenia treatment and patient life quality.

Keyword

Schizophrenia; Drug therapy; Antipsychotic agents; 조현병; 약물요법; 항정신병약물