Korean J Transplant.  2023 Nov;37(Suppl 1):S50. 10.4285/ATW2023.F-6158.

Metabolic clinic for living kidney donors: a pilot study

• Wattanatorn S
• Udomkarnjananun S
• Townamchai, N
• Avihingsanon Y
• Metta K

• KMID: 2551637
• DOI: http://doi.org/10.4285/ATW2023.F-6158

Abstract

Background
Living kidney donors are at higher risk of developing chronic kidney disease compared with the healthy nondonor population. The objective of this study was to examine the effect of postdonation interventions to decrease the risk of metabolic syndrome in high-risk donors.
Methods
Kidney donors were invited to participate this study if one of the following criteria were met: waist circumference larger than 80 cm in female or 90 cm in male, fasting blood glucose (FBG) higher than 100 mg/dL, serum triglyceride (TG) higher than 150 mg/dL, serum high-density lipoprotein (HDL) lower than 50 mg/dL in female or 40 mg/dL in male, or blood pressure higher than 130/85 mmHg. The interventions were (1) nutrition and diet counseling by dietitian, who also gave feedback on every meal of the participants, (2) blood pressure and steps counting by smart watches, and (3) exercise monitoring. The online social platform was created and joined by participants and investigators. The primary outcome was the changes of metabolic profile including FBG, TG, blood pressure, and waist circumference.
Results
Fifteen donors with high risk of metabolic syndrome were included. After 2 months of follow up, FBG was decreased from 101.3±11.0 mg/dL to 100.3±7.3 mg/dL, with an average of 0.8% reduction. Serum TG was decreased from 150±49 mg/dL to 117±36 mg/dL (average 11.1% reduction). Four percent of donors experienced decreased waist circumference more than 3%. Fi-nally, decreased systolic blood pressure of more than 5% was achieved in 5.2% of donors. 100% adherence rate were observed during the follow up period.
Conclusions
This pilot metabolic clinic for living kidney donors led to an improvement in donor health. Future study that includes more donors with longer follow up period in this metabolic clinic, compared with the traditional post-donation care, will enlighten the benefit of this intervention.