Korean J Transplant.  2021 Oct;35(Supple 1):S27. 10.4285/ATW2021.OP-1073.

Gestational hypertension and preeclampsia after kidney donation: a nationwide population-based cohort study from Korea

• Lee HS
• Lee J
• Huh KH
• Yoon SR

• KMID: 2521238
• DOI: http://doi.org/10.4285/ATW2021.OP-1073

Abstract

Background
Living kidney donation has known to increase the risk of gestational hypertension or preeclampsia. However, pregnancy outcomes in Asian living kidney donors are scarce.
Methods
We performed a retrospective cohort study on 112 living kidney donors and 672 healthy non-donors using the Korean National Health Insurance Claims database from 2007 to 2018. Donors and non-donors were matched with respect to age, residency, income, insurance, and number of pregnancies.
Results
Gestational hypertension or preeclampsia was more common in living kidney donors than in non-donors (12 of 112 donors [10.71%] vs. 37 of 672 non-donors [5.51%]; odds ratio, 1.99; 95% confidence interval, 1.04–3.82; P=0.03). Use of antihypertensive drugs during preeclampsia was also more common in donors than in non-donors (3 of 112 donors [2.68%] vs. 4 of non-donors [0.60%]; odds ratio, 4.56; 95% confidence interval, 1.02–20.37; P<0.01). There were no significant differences in preterm birth and low birth weight between two groups. There were no reports of maternal death or neonatal death in the donors.
Conclusions
Our findings indicate that living kidney donors appear to be associated with increased risk of gestational hypertension or preeclampsia compared to matched healthy non-donors.