Investig Magn Reson Imaging.  2023 Dec;27(4):221-225. 10.13104/imri.2023.0013.

Quantitative Susceptibility Mapping of Oxygen Metabolism: A Feasibility Study Utilizing a Large-Scale Clinical Dataset

• Chung W
• Jang J
• Nam Y

• KMID: 2550189
• DOI: http://doi.org/10.13104/imri.2023.0013

Abstract

Purpose
The aim of the present study was to investigate the potential utility of the magnetic susceptibility-based assessment of cerebral oxygen metabolism with a dataset from a memory clinic.
Materials and Methods
We collected and processed three-dimensional gradient-recalled echo phase data of 290 participants. To analyze oxygen metabolism, quantitative susceptibility mapping was performed for two major veins (superior sagittal sinus and straight sinus), and the venous oxygen saturation was estimated.
Results
The estimated venous oxygen saturations of the two major veins were positively correlated with the clinical and volumetric measurements. They did not differ with the clinical diagnosis or clinical dementia rating. The values of the superior sagittal sinus were associated with the presence of the apolipoprotein E type 4 allele, when considering age, sex, and their interactions.
Conclusion
The results demonstrate that quantitative susceptibility mapping of clinically available three-dimensional susceptibility-weighted imaging sequences in a large-scale clinical dataset can estimate cerebral oxygen metabolism.

Keyword

Brain oxygenation; Oxygen extraction fraction; Quantitative susceptibility mapping; Venous oxygen saturation