Ann Dermatol.  2023 Nov;35(Suppl2):S281-S286. 10.5021/ad.21.307.

Cases of Pernio-Like Lesions after mRNA-1273 Vaccination with Clinical and Pathological Features: A Single-Center Experience

• Ryoo YW
• Yun JM
• Kim HW
• Lee HW
• Jung HR
• Kim SA

• KMID: 2548874
• DOI: http://doi.org/10.5021/ad.21.307

Abstract

The currently available coronavirus disease 2019 (COVID-19) vaccines in South Korea include mRNA (Moderna^® and Pfizer^®) and adenoviral vector (AstraZeneca^® and Janssen^® ) vaccines. Dermatologic side effects of COVID-19 vaccines range from local injection site reactions to systemic eruptions, including morbilliform rashes or erythema multiforme. Pernio-like lesions, one of the most common cutaneous manifestations of COVID-19, have been rarely reported post-vaccination. Herein, we report four cases of pernio-like lesions, which were detected in a single tertiary hospital within 2 months, after the first dose of mRNA-1273 (Moderna^® ) vaccination was administered. In this study, we discuss the clinical and pathological features of our cases and compare them with those of previously reported cases of pernio-like lesions after COVID-19 vaccination. It is pivotal to realize that perniolike lesions can be a possible side effect of COVID-19 vaccination and that the number of patients experiencing this side effect is bound to be quite high in real-world clinical settings.

Keyword

Adverse drug reactions; Chilblains; COVID-19; mRNA-1273