Clin Exp Vaccine Res.  2022 Jan;11(1):121-124. 10.7774/cevr.2022.11.1.121.

Severity of adverse reactions is associated with T-cell response in mRNA-1273 vaccinated health care workers

• Klingel H
• Lauen M
• Krüttgen A
• Imöhl M
• Kleines M

• KMID: 2534935
• DOI: http://doi.org/10.7774/cevr.2022.11.1.121

Abstract

Knowledge about mRNA-1273 elicited T-cell response is limited. We investigated adverse reactions and interferon gamma release by specific T-cells among mRNA-1273 vaccinated health care workers. Seven to 13 weeks after complete vaccination low levels of specific T-cells were detected not correlating with antibody response. Severity of symptoms after first and number of symptoms after second immunization were associated with T-cell response. Assessment of T-cell response in addition to antibody response is crucial because even few specific T-cells could add to protection against infection. Investigation of mRNA-1273 induced inflammatory processes might help improve reactogenicity and immunogenicity.

Keyword

Adverse reactions; Antibody response; SARS-CoV-2; T-cell response; Vaccine mRNA-1273