Korean Circ J.  2023 Dec;53(12):855-857. 10.4070/kcj.2023.0278.

The Obesity Paradox: An Epiphenomenon vs. A Clue for the Hidden Pathophysiology of Adiposity

• Hwang IC

• KMID: 2548793
• DOI: http://doi.org/10.4070/kcj.2023.0278

Figure

• 

  Figure 1 Explanations, potential mechanisms, and debates regarding the obesity paradox.BMI = body-mass index; CV = cardiovascular.

Reference

1. Fleischmann E, Teal N, Dudley J, May W, Bower JD, Salahudeen AK. Influence of excess weight on mortality and hospital stay in 1346 hemodialysis patients. Kidney Int. 1999; 55:1560–1567. PMID: 10201023.

2. Gruberg L, Weissman NJ, Waksman R, et al. The impact of obesity on the short-term and long-term outcomes after percutaneous coronary intervention: the obesity paradox? J Am Coll Cardiol. 2002; 39:578–584. PMID: 11849854.

3. Hwang IC, Choi HM, Yoon YE, et al. Body mass index, muscle mass, and all-cause mortality in patients with acute heart failure: the obesity paradox revisited. Int J Heart Fail. 2022; 4:95–109. PMID: 36263103.

4. Lim C, Won H, Ko YG, et al. K-VIS Investigators. Association between body mass index and clinical outcomes of peripheral artery disease after endovascular therapy: data from K-VIS ELLA registry. Korean Circ J. 2021; 51:696–707. PMID: 34327883.

5. Horwich TB, Fonarow GC, Hamilton MA, MacLellan WR, Woo MA, Tillisch JH. The relationship between obesity and mortality in patients with heart failure. J Am Coll Cardiol. 2001; 38:789–795. PMID: 11527635.

6. Banack HR, Kaufman JS. Does selection bias explain the obesity paradox among individuals with cardiovascular disease? Ann Epidemiol. 2015; 25:342–349. PMID: 25867852.

7. Valenzuela PL, Carrera-Bastos P, Castillo-García A, Lieberman DE, Santos-Lozano A, Lucia A. Obesity and the risk of cardiometabolic diseases. Nat Rev Cardiol. 2023; 20:475–494. PMID: 36927772.

8. Choi SH, Ku EJ, Hong ES, et al. High serum adiponectin concentration and low body mass index are significantly associated with increased all-cause and cardiovascular mortality in an elderly cohort, “adiponectin paradox”: the Korean Longitudinal Study on Health and Aging (KLoSHA). Int J Cardiol. 2015; 183:91–97. PMID: 25662058.

9. Antonopoulos AS, Tousoulis D. The molecular mechanisms of obesity paradox. Cardiovasc Res. 2017; 113:1074–1086. PMID: 28549096.

10. Kim BG, Kim BK, Lee YJ, et al. Association between body mass index and clinical outcomes according to diabetes in patients who underwent percutaneous coronary intervention. Korean Circ J. 2023; 53:843–854. PMID: 37973975.