Korean J Head Neck Oncol.
2023 Nov;39(2):45-48. 10.21593/kjhno/2023.39.2.45.
A Case of Early Malignant Change from Neurofibroma to Malignant Peripheral Nerve Sheath Tumor
- Affiliations
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- 1Department of Otolaryngology, Head and Neck Surgery, Kosin University College of Medicine, Busan, Korean
- 2Department of Pathology, Department of Pathology, Kosin University College of Medicine, Busan, Korean
- KMID: 2548694
- DOI: http://doi.org/10.21593/kjhno/2023.39.2.45
Abstract
- Malignant peripheral nerve sheath tumor (MPNST) is one of the soft tissue sarcoma believed to originate from neural crest cells. The patients with neurofibromatosis type I (NF1) have about 8-13% of the lifetime risk of the malignant transformation. Neurofibroma on patients with NF1 can be surgically resected and has good prognosis if approach to the tumor is possible. We experienced a case of a 50-year-old woman with NF who had incompletely resected neurofibroma, which presented a rapid malignant transformation to MPNST, 3 months after the first surgery. We reported this case with a brief review of literature.
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