Korean J Orthod.  2023 Nov;53(6):374-392. 10.4041/kjod22.272.

Periodontal health status, oral microbiome, whitespot lesions and oral health related to quality of life-clear aligners versus fixed appliances: A systematic review, meta-analysis and meta-regression

• Llera-Romero AS
• Adobes-Martín M
• Iranzo-Cortés JE
• Montiel-Company JM
• Garcovich D

• KMID: 2548482
• DOI: http://doi.org/10.4041/kjod22.272

Abstract

Objective
Assess and evaluate the different indicators of oral health-related quality of life (OHRQoL) among patients treated with clear aligners (CAs) versus those treated with conventional fixed orthodontics (FAs).
Methods
An electronic search was performed on the database is Web of Science, Scopus, and Embase databases. Randomized and non-randomized control trials, cross-sectional, prospective cohort and retrospective trials were included. Quality was assessed with risk of bias tool and risk of bias in non-randomised studies. Meta-analyses were performed with random effects models, estimating the standardized and non-standardized mean differences, odds ratio and risk ratio as the measure of effect. The effect on time was determined using a meta-regression model.
Results
Thirty one articles were included in the qualitative synthesis and 17 in the meta-analysis. CAs had a significantly lower negative impact on QoL, with an “important” effect size, while the influence of time was not significant. Periodontal indicators plaque index (PI), gingival index (GI), probing depth (PD), and bleeding on probing show significantly better values in patients treated with CAs, with moderate to large effect sizes. PI and GI have a significant tendency to improve over time. In microbiological indicators, CAs present a lower biofilm mass without differences in the percentage of patients with high counts of Streptococcus mutans and Lactobacilli bacteria. The risk of white spot lesion onset is ten times lower in carriers of CAs.
Conclusions
Patients wearing CAs show better periodontal indicators, less risk of white spot development, less biofilm mass and a better QoL than patients with FAs.

Keyword

Removable; Tooth movement; Orthodontic treatment

Figure

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  Figure 1 Flow diagram.

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  Figure 2 Oral health-related quality of life meta-analysis and Forest plot. Std diff, standard difference; CI, confidence interval.

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  Figure 3 Plaque index at 1, 3, and 6–12 months into treatment meta-analysis and Forest plot. Std diff, standard difference; CI, confidence interval.

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  Figure 4 Gingival bleeding at 1, 3, and 6–12 months into treatment meta-analysis and Forest plot. Std diff, standard difference; CI, confidence interval.

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  Figure 5 Meta-regression scatter plot of plaque index standardized difference in mean at different time points (months). Std diff, standard difference.

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  Figure 6 Meta-regression scatter plot of gingival bleeding index standardized difference in mean at different time points (months). Std diff, standard difference.

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  Figure 7 Probing depth at 1 and 3 months into treatment meta-analysis and Forest plot. CI, confidence interval.

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  Figure 8 Gingival index 6–12 months into treatment meta-analysis and Forest plot. Std diff, standard difference; CI, confidence interval.

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  Figure 9 Biofilm mass 1 month into treatment meta-analysis and Forest plot. Std diff, standard difference; CI, confidence interval.

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  Figure 10 Odds ratio of high concentration of Streptococcus mutans between 4 and 12 weeks into treatment, Forest plot and meta-analysis. CI, confidence interval.

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  Figure 11 Odds ratio of high concentration of Lactobacillus between 4 and 12 weeks into treatment, Forest plot and meta-analysis. CI, confidence interval.

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  Figure 12 Odds ratio of white spot lesions prevalence at the end of treatment, Forest plot and meta-analysis. WSL, white spot lesions; CI, confidence interval.

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