J Yeungnam Med Sci.  2023 Nov;40(Suppl):S137-S141. 10.12701/jyms.2023.00864.

Cephalosporin-induced encephalopathy in patients with hematologic malignancies: a significant concern

• Park YS
• Kim MK
• Lee KH
• Koh SA
• Jung JY
• Jang BI
• Lee SJ

• KMID: 2548357
• DOI: http://doi.org/10.12701/jyms.2023.00864

Figure

• 

  Fig. 1. Initial electroencephalography shows unilateral, bifrontal, or generalized quasiperiodic high amplitude spike or sharp and slow wave complexes at 1 to 2 Hz with anterior-to-posterior time lags and an amplitude gradient.

• 

  Fig. 2. Follow-up electroencephalography shows diffuse frontal dominant theta waves at 7 Hz mixed with small beta waves.

Reference

References

1. Appa AA, Jain R, Rakita RM, Hakimian S, Pottinger PS. Characterizing cefepime neurotoxicity: a systematic review. Open Forum Infect Dis. 2017; 4:ofx170.

2. Fugate JE, Kalimullah EA, Hocker SE, Clark SL, Wijdicks EF, Rabinstein AA. Cefepime neurotoxicity in the intensive care unit: a cause of severe, underappreciated encephalopathy. Crit Care. 2013; 17:R264.

3. Kang JK, Kim SB. Neurotoxicity by cefepime: case-control study. J Neurocrit Care. 2014; 7:104–10.

4. Lee SJ. Cefepime-induced neurotoxicity. J Neurocrit Care. 2019; 12:74–84.

5. Al-Sadawi M, Rodriguez Ortega R, Sun N, Abdurahimova M, McFarlane SI. Jerky movement with ceftazidime: a case of ceftazidime-induced neurotoxicity with a review of the literature. Case Rep Med. 2019; 2019:8936478.

6. Keerty D, Shareef NA, Ramsakal A, Haynes E, Syed M. Cefepime-induced encephalopathy. Cureus. 2021; 13:e13125.

7. Payne LE, Gagnon DJ, Riker RR, Seder DB, Glisic EK, Morris JG, et al. Cefepime-induced neurotoxicity: a systematic review. Crit Care. 2017; 21:276.

8. Triplett JD, Lawn ND, Chan J, Dunne JW. Cephalosporin-related neurotoxicity: metabolic encephalopathy or non-convulsive status epilepticus? J Clin Neurosci. 2019; 67:163–6.

9. Boschung-Pasquier L, Atkinson A, Kastner LK, Banholzer S, Haschke M, Buetti N, et al. Cefepime neurotoxicity: thresholds and risk factors. A retrospective cohort study. Clin Microbiol Infect. 2020; 26:333–9.