J Lipid Atheroscler.  2023 Sep;12(3):223-236. 10.12997/jla.2023.12.3.223.

Mechanisms of the Wnt Pathways as a Potential Target Pathway in Atherosclerosis

• Poznyak AV
• Sukhorukov VN
• Popov MA
• Chegodaev YS
• Postnov AY
• Orekhov AN

• KMID: 2546556
• DOI: http://doi.org/10.12997/jla.2023.12.3.223

Abstract

The proteins of the Wnt family are involved in a variety of physiological processes by means of several canonical and noncanonical signaling pathways. Wnt signaling has been recently identified as a major player in atherogenesis. In this review, we summarize the existing knowledge on the influence of various components of the Wnt signaling pathways on the initiation and progression of atherosclerosis and associated conditions. We used the PubMed database to search for recent papers on the involvement of the Wnt pathways in atherosclerosis. We used the combination of “Wnt” and “atherosclerosis” keywords to find the initial papers, and chose papers published after 2018. In the first section of the paper, we describe the general mechanisms of the Wnt signaling pathways and their components. The next section is dedicated to existing studies assessing the implication of Wnt signaling elements in different atherogenic processes, such as cholesterol retention, endothelial dysfunction, vascular inflammation, and atherosclerotic calcification of the vessels. Lastly, various therapeutic strategies based on interference with the Wnt signaling pathways are considered. We also compare the efficacy and availability of the proposed treatment methods. Wnt signaling can be considered a potential target in the treatment and prevention of atherosclerosis. Therefore, in this review, we reviewed evidences showing that wnt signaling is an important signal for developing appropriate treatment strategies for atherosclerosis.

Keyword

Wnt signaling; Atherosclerosis; Cardiovascular disease