Blood Res.  2023 Sep;58(3):148-151. 10.5045/br.2023.2023114.

Hairy cell leukemia presenting as a pleural mass without leukemic component: a case report

• Alshomrani A
• Cannatella JJ
• Qureishi H

• KMID: 2546317
• DOI: http://doi.org/10.5045/br.2023.2023114

Figure

• 

  Fig. 1 Pleural-based mass involved by Hairy cell leukemia. All stains at ×20. Hematoxylin & eosin (A) stain shows small to medium sized cells with interspersed histiocytes. Immunohistochemical studies confirmed these cells to be CD20 (B), CD123 (C), annexin A1 (D) BRAFV600E (E), and cyclin D1 (F). Kappa (G) and Lambda (H) in situ hybridization demonstrates kappa light chains restriction.

• 

  Fig. 2 Flow cytometry analysis demonstrates a population of mature B-cells with a high-density expression of CD11c, CD25, CD103, and Lambda light chain restriction.

• 

  Fig. 3 DNA amplification and pyro-sequencing analysis BRAF molecular mutation (p.Val600Glu; p.V600E) in codon 600 of the BRAF gene.

Reference

1. Swerdlow SH, Campo E, Pileri SA, et al. 2016; The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood. 127:2375–90. DOI: 10.1182/blood-2016-01-643569. PMID: 26980727. PMCID: PMC4874220.

2. Dores GM, Matsuno RK, Weisenburger DD, Rosenberg PS, Anderson WF. 2008; Hairy cell leukaemia: a heterogeneous disease? Br J Haematol. 142:45–51. DOI: 10.1111/j.1365-2141.2008.07156.x. PMID: 18477040. PMCID: PMC4009349.

3. Tiacci E, Trifonov V, Schiavoni G, et al. 2011; BRAF mutations in hairy-cell leukemia. N Engl J Med. 364:2305–15. DOI: 10.1056/NEJMoa1014209. PMID: 21663470. PMCID: PMC3689585.

4. Cortazar JM, DeAngelo DJ, Pinkus GS, Morgan EA. 2017; Mor-phological and immunophenotypical features of hairy cell leukaemia involving lymph nodes and extranodal tissues. Histopathology. 71:112–24. DOI: 10.1111/his.13206. PMID: 28261866.

5. Hammond WA, Swaika A, Menke D, Tun HW. 2017; Hairy cell lymphoma: a potentially under-recognized entity. Rare Tumors. 9:6518. DOI: 10.4081/rt.2017.6518. PMID: 28458788. PMCID: PMC5379228. PMID: 37c1d1d23bb54e14887c8abc7cfdabda.

6. Rosen DS, Smith S, Gurbuxani S, Yamini B. 2008; Extranodal hairy cell leukemia presenting in the lumbar spine. J Neurosurg Spine. 9:374–6. DOI: 10.3171/SPI.2008.9.10.374. PMID: 18939925.

7. Choi WW, Weisenburger DD, Greiner TC, et al. 2009; A new immunostain algorithm classifies diffuse large B-cell lymphoma into molecular subtypes with high accuracy. Clin Cancer Res. 15:5494–502. DOI: 10.1158/1078-0432.CCR-09-0113. PMID: 19706817. PMCID: PMC7289055.

8. Chadha P, Rademaker AW, Mendiratta P, et al. 2005; Treatment of hairy cell leukemia with 2-chlorodeoxyadenosine (2-CdA): long-term follow-up of the Northwestern University experience. Blood. 106:241–6. DOI: 10.1182/blood-2005-01-0173. PMID: 15761021.

9. Saven A, Burian C, Koziol JA, Piro LD. 1998; Long-term follow-up of patients with hairy cell leukemia after cladribine treatment. Blood. 92:1918–26. DOI: 10.1182/blood.V92.6.1918. PMID: 9731048.