Blood Res.  2018 Jun;53(2):160-163. 10.5045/br.2018.53.2.160.

Synchronous hairy cell leukemia and chronic lymphocytic leukemia: a case report with a brief review of literature

• Rastogi P
• Jeyaraman
• Sachdeva M
• Malhotra P
• Ahluwalia

• KMID: 2451035
• DOI: http://doi.org/10.5045/br.2018.53.2.160

Abstract

No abstract available.

MeSH Terms

Leukemia, Hairy Cell*
Leukemia, Lymphocytic, Chronic, B-Cell*

Figure

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  Fig. 1 Morphological and immunophenotypic findings of the neoplastic cells. (A) Peripheral blood smear showing a typical “hairy” cell (May-Grunwald Giemsa stain, ×1,000). (B) Trephine biopsy showing predominantly “hairy” cells with fried egg appearance and an interstitial nodule of mature appearing lymphoid cells (H & E stain, ×600). (C, D) Immunohistochemistry for CD5 and CD23 respectively showing positivity in interstitial nodules of lymphoid cells (Hematoxylin counterstain, ×400). (E, F) Immunohistochemistry for CD20 and DBA.44 highlighting the “hairy” cells and negative in lymphoid nodule (Hematoxylin counterstain, ×400).

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  Fig. 2 Immunophenotyping of the neoplastic cells in bone marrow aspirate at the time of diagnosis by four-color flow cytometry (dot-plot analysis). CLL/SLL cells (sky-blue) showing characteristic phenotype: CD5+, CD23+, sIgweak+, CD20weak+ and CD10− whereas HCL cells (purple) showing CD20bright+, CD25+, CD103+, CD11cbright+, sIgλ+, CD23−, CD5−, and CD10−.

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