Ann Lab Med.  2019 Nov;39(6):577-579. 10.3343/alm.2019.39.6.577.

First Case of Transformation of Immunoglobulin Heavy Chain Variable-Mutated Chronic Lymphocytic Leukemia Into Chronic Myeloid Leukemia

• Zhang X
• Guo X

• KMID: 2450954
• DOI: http://doi.org/10.3343/alm.2019.39.6.577

Abstract

No abstract available.

MeSH Terms

Immunoglobulin Heavy Chains*
Immunoglobulins*
Leukemia, Lymphocytic, Chronic, B-Cell*
Leukemia, Myelogenous, Chronic, BCR-ABL Positive*
Immunoglobulin Heavy Chains
Immunoglobulins

Figure

• 

  Fig. 1 Results of karyotyping and FISH. (A) Cytogenetic tests revealed 46,XY, t(9;22)(q34;q11.2) [20]. (B) FISH detected the presence of BCR-ABL fusion gene.

Reference

1. Hatoum HA, Mahfouz RA, Otrock ZK, Hudaib AR, Taher AT, Shamseddine AI. Acute myeloid leukemia with T-cell receptor gamma gene rearrangement occurring in a patient with chronic lymphocytic leukemia: a case report. Am J Hematol. 2007; 82:69–72. PMID: 16947317.

2. Garcia-Manero G, Faderl S, O'Brien S, Cortes J, Talpez M, Kantarjan HM. Chronic myelogenous leukemia: a review and update of therapeutic strategies. Cancer. 2003; 98:437–457. PMID: 12879460.

3. Mansat-De Mas V, Rigal-Huguet F, Cassar G, Kuhlein E, Laurent G, Dastugue N. Chronic myeloid leukemia associated with B-cell chronic lymphocytic leukemia: evidence of two separate clones as shown by combined cell-sorting and fluorescence in situ hybridisation. Leuk Lymphoma. 2003; 44:867–869. PMID: 12802927.

4. Morrison VA, Rai KR, Peterson BL, Kolitz JE, Elias L, Appelbaum FR, et al. Therapy-related myeloid leukemias are observed in patients with chronic lymphocytic leukemia after treatment with fludarabine and chlorambucil: results of an intergroup study, cancer and leukemia group B 9011. J Clin Oncol. 2002; 20:3878–3884. PMID: 12228208.

5. Crescenzi B, Sacchi S, Marasca R, Temperani P, La Starza R, Matteucci C, et al. Distinct genomic events in the myeloid and lymphoid lineages in simultaneous presentation of chronic myeloid leukemia and B-chronic lymphocytic leukemia. Leukemia. 2002; 16:955–956. PMID: 11986962.

6. Tsimberidou AM, Keating MJ. Richter's transformation in chronic lymphatic leukemia. Semin Oncol. 2006; 33:250–256. PMID: 16616072.

7. Jelinek DF, Tschumper RC, Geyer SM, Bone ND, Dewald GW, Hanson CA, et al. Analysis of clonal B-cell CD38 and immunoglobulin variable region sequence status in relation to clinical outcome for B-chronic lymphocytic leukaemia. Br J Haematol. 2001; 115:854–861. PMID: 11843819.

8. Parikh SA, Shanafelt TD. Risk factors for Richter syndrome in chronic lymphocytic leukemia. Curr Hematol Malig Rep. 2014; 9:294–299. PMID: 25218362.

9. Spencer A, Szydlo R, Grand FH, Goldman JM, Melo JV. Abnormal patterns of immunoglobulin heavy chain gene DNA fingerprinting during chronic phase chronic myeloid leukemia. Leuk Lymphoma. 1999; 32:299–307. PMID: 10037027.

10. Kiyoi H, Fukutani H, Yamauchi T, Kubo K, Ohno R, Yamamori S, et al. Continuing immunoglobulin heavy chain gene rearrangements in chronic myeloid leukemia with recurrent B-lymphoid blast crisis after bone marrow transplantation. Leukemia. 1995; 9:265–270. PMID: 7869762.