Allergy Asthma Respir Dis.  2023 Jul;11(3):161-163. 10.4168/aard.2023.11.3.161.

Bird-Egg syndrome diagnosed by ImmunoCap ISAC

• Chung J
• Lee D
• Hwang Y

• KMID: 2545011
• DOI: http://doi.org/10.4168/aard.2023.11.3.161

Abstract

Adult-onset egg allergy is rare compared to child-onset egg allergy, and the component-resolved diagnosis test is effective in evaluating food allergy. We herein report a 24-year-old woman with late-onset egg-yolk allergy diagnosed as bird-egg syndrome. The prolonged exposure to pet parrots' dander or dropping through the respiratory system caused sensitization to the Gal d 5 component and resulted in a cross-reaction to egg yolk. Since the patient was suspected of the syndrome by her history, the skin prick test, ISAC ImmunoCAP, and serum ImmunoCAP test were performed. By confirming Gal d 5 component by ISAC ImmunoCAP, the patient was diagnosed with the syndrome. In patients with newly adult-onset food allergy, the clinician must identify the environmental conditions which can cause cross-sensitization and perform the causative component test.

Keyword

Bird-egg syndrome; Egg-yolk allergy; α-livetin; Gal d 5; ImmunoCAP; ISAC