J Korean Neurol Assoc.
2023 Aug;41(3):220-224. 10.17340/jkna.2023.3.8.
Generalized Tetanus Treated with Intrathecal Baclofen Infusion
- Affiliations
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- 1Departments of Neurology, Pusan National University Yangsan Hospital, Yangsan, Korea
- 2Departments of Anethesia and Pain Medicine, Pusan National University Yangsan Hospital, Yangsan, Korea
- 3Department of Anesthesia and Pain medicine, Pusan National University School of Medicine, Yangsan, Korea
- 4Department of Pharmacy, Pusan National University Yangsan Hospital, Yangsan, Korea
- 5Department of Neurology, Pusan National University School of Medicine, Yangsan, Korea
- KMID: 2544803
- DOI: http://doi.org/10.17340/jkna.2023.3.8
Abstract
- Tetanus is a bacterial infection by Clostridium tetani. Its neurotoxin causes spastic paralysis and autonomic dysfunction. Intrathecal infusion of baclofen has been suggested as a pertinent treatment for generalized spasm. Our case describes a patient who had a severe generalized form of tetanus, and was effectively treated with intrathecal baclofen infusion. He showed cerebral and brainstem dysfunction during baclofen infusion, which were reversed without sequelae when baclofen was discontinued.
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