Int J Arrhythm.  2023 Jun;24(2):13. 10.1186/s42444-023-00096-0.

Pulmonary veins isolation using cryoballoon and pulsed field ablation for atrial fibrillation: practical techniques in variable scenarios

  • 1Cardioangiologisches Centrum Bethanien (CCB), Kardiologie, Medizinische Klinik III, Agaplesion Markus Krankenhaus, Akademisches Lehrkrankenhaus der Goethe-Universität Frankfurt Am Main, Frankfurt am Main, Germany
  • 2Die Sektion Medizin, Universität zu Lübeck, Lübeck, Germany


Catheter ablation is the most effective treatment for atrial fibrillation (AF). Electrical pulmonary veins isolation (PVI) forms the cornerstone ablation strategy. Radiofrequency (RF) in combination with 3D mapping system is the traditional ablation approach to treat AF. As a single-shot ablation system, cryoballoon (CB) has been an established ablation modality to facilitate PVI procedure. As a novel non-thermal single-shot ablation technology, pulsed field ablation (PFA) has its unique biophysical profile. Recent studies have demonstrated that PFA allows for efficient and durable PVI. However, the manipulation of single-shot ablation catheter may be different from the conventional point-bypoint RF ablation catheter; ablation catheter with fixed size may have practical difficulties in variable anatomy and different clinical scenarios. The present article focuses on the technical aspects, describes the procedural approaches and illustrates the practical techniques of using CB and PFA for PVI, ultimately with the purpose to facilitate the ablation procedure and improve the patients’ clinical outcome.


Atrial fibrillation; Catheter ablation; Cryoballoon; Pulsed field ablation; Practical technique
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