Korean J Vet Res.  2023 Jun;63(2):e8. 10.14405/kjvr.20230006.

Successful long-term management of late-stage precursor-targeted immune-mediated anemia with prednisolone and mycophenolate mofetil in a dog

• Kim D
• Song WJ
• Kim SS
• Jeong S
• Hong HJ
• Yun Y

• KMID: 2543755
• DOI: http://doi.org/10.14405/kjvr.20230006

Abstract

A 13-year-old neutered male Maltese dog presented to our hospital with lethargy and anorexia. Laboratory abnormalities included severe non-regenerative anemia (hematocrit, 12.9%; reticulocyte count 12.8 K/μL). The cytology of bone marrow revealed erythroid hypercellularity with mild myelofibrosis. Therefore, late-stage precursor-targeted immune-mediated anemia (PIMA) was diagnosed. Multimodal treatment including 2 immunosuppressant drugs (prednisolone and mycophenolate mofetil), antithrombic drug (clopidogrel), and blood transfusion was performed. The dog showed complete remission from PIMA, and the total duration of follow-up was 622 days. This is the first case report of canine PIMA managed successfully with prednisolone and mycophenolate mofetil in Korea.

Keyword

case report; precursor-targeted immune-mediated anemia; dogs; bone marrow examination; mycophenolate mofetil