Anesth Pain Med.  2023 Apr;18(2):190-197. 10.17085/apm.23005.

Wound infiltration or transversus abdominis plane block after laparoscopic radical prostatectomy: a randomized clinical trial

• Tejedor A
• Deiros C
• Bijelic L
• García M

• KMID: 2543660
• DOI: http://doi.org/10.17085/apm.23005

Abstract

Background
Regional anesthesia techniques are commonly used for postoperative pain management during laparoscopic surgery. Our aim was to compare the analgesic efficacy of pre-incisional subcutaneous wound infiltration (WI) with that of the transversus abdominis plane (TAP) block as part of a multimodal analgesic approach in laparoscopic radical prostatectomy.
Methods
In this prospective, double-blinded, randomized controlled clinical trial, 60 patients were assigned to either TAP or WI group. The main outcome was acute postoperative pain control assessed using the mean numeric rating scale (NRS) at the 24 hours postoperatively. The secondary outcomes were opioid requirements, procedure-related complications, overall complications, and length of stay.
Results
In this study, 60 patients were randomized: 30 to TAP group and 28 to WI (two were excluded due to conversion to open surgery). We found no significant difference in the median (1Q, 3Q) NRS scores during the 24 h postoperatively neither at rest (TAP, 0 (0, 1) vs. WI, 0 (0, 1), P = 0.812), nor during movement (TAP, 1 (0, 2) vs. WI, 1 (0, 2), P = 0.708). There were no statistical differences in the postoperative intravenous morphine requirements in the TAP vs. WI groups during the same period (1.7 ± 3.1 vs. 1.8 ± 4.1 mg; P = 0.910). Only one patient in the TAP group presented with postoperative nausea and vomiting.
Conclusions
Both pre-incisional subcutaneous WI and TAP blockade were associated with very low pain scores as part of a non-opioid multimodal analgesic regimen in laparoscopic radical prostatectomy. This study did not demonstrate the benefits of WI over TAP.

Keyword

Enhanced recovery after surgery; Laparoscopic prostatectomy; Multimodal analgesia; Transversus abdominis plane block; Wound infiltration

Figure

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  Fig. 1. CONSORT diagram. CONSORT: consolidated standards of reporting trials, TAP: transversus abdominis plane.

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  Fig. 2. Numeric Rate Scale (NRS) scores at rest and during cough in the first 4 postoperative hours in the TAP and WI groups. Median (line within box), interquartile range (box) and range (error bars) are shown. No statistically significant differences are observed between the analgesic efficacies of the two procedures. TAP: transversus abdominis plane, WI: wound infiltration.

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  Fig. 3. Numeric rate scale (NRS) scores during movement during the first 48 postoperative hours in the TAP and WI groups. Median (line within box), interquartile range (box) and range (error bars) are shown. No statistically significant differences are observed between the analgesic efficacies of the two procedures. TAP: transversus abdominis plane, WI: wound infiltration.

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