Diabetes Metab J.  2023 May;47(3):426-436. 10.4093/dmj.2022.0099.

Novel Asian-Specific Visceral Adiposity Indices Are Associated with Chronic Kidney Disease in Korean Adults

• Jin J
• Woo H
• Jang Y
• Lee WK
• Kim JG
• Lee IK
• Park KG
• Choi YK

• KMID: 2542519
• DOI: http://doi.org/10.4093/dmj.2022.0099

Abstract

Background
The Chinese visceral adiposity index (CVAI) and new visceral adiposity index (NVAI) are novel indices of visceral adiposity used to predict metabolic and cardiovascular diseases in Asian populations. However, the relationships of CVAI and NVAI with chronic kidney disease (CKD) have not been investigated. We aimed to characterize the relationships of CVAI and NVAI with the prevalence of CKD in Korean adults.
Methods
A total of 14,068 participants in the 7th Korea National Health and Nutrition Examination Survey (6,182 men and 7,886 women) were included. Receiver operating characteristic (ROC) analyses were employed to compare the associations between indices of adiposity and CKD, and a logistic regression model was used to characterize the relationships of CVAI and NVAI with CKD prevalence.
Results
The areas under the ROC curves for CVAI and NVAI were significantly larger than for the other indices, including the visceral adiposity index and lipid accumulation product, in both men and women (all P<0.001). In addition, high CVAI or NVAI was significantly associated with a high CKD prevalence in both men (odds ratio [OR], 2.14; 95% confidence interval [CI], 1.31 to 3.48 in CVAI and OR, 6.47; 95% CI, 2.91 to 14.38 in NVAI, P<0.05) and women (OR, 4.87; 95% CI, 1.85 to 12.79 in CVAI and OR, 3.03; 95% CI, 1.35 to 6.82 in NVAI, P<0.05); this association remained significant after adjustment for multiple confounding factors in men and women.
Conclusion
CVAI and NVAI are positively associated with CKD prevalence in a Korean population. CVAI and NVAI may be useful for the identification of CKD in Asian populations, including in Korea.

Keyword

Body fat distribution; Intra-abdominal fat; Obesity; Renal insufficiency; chronic

Figure

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  Fig. 1 Scatter plots of Pearson’s correlations of estimated glomerular filtration rate (eGFR) with age, lipid accumulation product (LAP), body mass index (BMI), visceral adiposity index (VAI), Chinese visceral adiposity index (CVAI), and new visceral adiposity index (NVAI). aP<0.01.

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  Fig. 2 Receiver operating characteristic curves in men (A) and women (B) for the associations Chinese visceral adiposity index (CVAI), and new visceral adiposity index (NVAI), visceral adiposity index (VAI), lipid accumulation product (LAP), and body mass index (BMI) with chronic kidney disease (CKD). CKD was defined using an estimated glomerular filtration rate of <60 mL/min/1.73 m2.

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