Ann Coloproctol.
2023 Apr;39(2):155-163. 10.3393/ac.2021.01032.0147.
The albumin to globulin ratio is associated with clinical outcome in Japanese patients with ulcerative colitis
- Yagi S1
- Furukawa S
2 - Shiraishi K3
- Miyake T3
- Tange K4
- Hashimoto Y3
- Kitahata S5
- Kawamura T5
- Ninomiya T5
- Mori K6
- Suzuki S7
- Shibata N8
- Murakami H1
- Ohashi K9
- Hasebe A10
- Tomida H11
- Yamamoto Y11
- Takeshita E4
- Ikeda Y11
- Hiasa Y3
- Affiliations
-
- 1Department of Internal Medicine, Saiseikai Matsuyama Hospital, Matsuyama, Japan
- 2Health Services Center, Ehime University, Matsuyama, Japan
- 3Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon, Japan
- 4Department of Inflammatory Bowel Diseases and Therapeutics, Ehime University Graduate School of Medicine, Toon, Japan
- 5Department of Gastroenterology, Ehime Prefectural Central Hospital, Matsuyama, Japan
- 6Department of Internal Medicine, Iyo Hospital, Iyo, Japan
- 7Department of Gastroenterology, Sumitomo Besshi Hospital, Niihama, Japan
- 8Department of Gastroenterology, Ehime Prefectural Niihama Hospital, Niihama, Japan
- 9OHASHI Clinic participate in Gastro-Enterology and Ano-Proctology, Niihama, Japan
- 10Department of Gastroenterology, Shikoku Cancer Center, Matsuyama, Japan
- 11Endoscopy Center, Ehime University Hospital, Toon, Japan
- KMID: 2541834
- DOI: http://doi.org/10.3393/ac.2021.01032.0147
Abstract
- Purpose
The albumin-to-globulin ratio (AGR) is a recognized chronic inflammation marker. No evidence regarding the relationship between AGR level and ulcerative colitis (UC) exists. The aim of this study was to evaluate the association between AGR and clinical outcomes among Japanese subjects with UC.
Methods
The study subjects consisted of 273 Japanese individuals with UC. AGR was divided into 4 categories (low, moderate, high, and very high). The definition of complete mucosal healing (MH) was based on the Mayo endoscopic subscore of 0. Clinical remission (CR) was defined as no rectal bleeding and no abnormally high stool frequency (<3 times per day).
Results
The percentage of MH was 26.4%. High AGR and very high AGR were significantly positively correlated with CR (adjusted odds ratio [OR], 5.85; 95% confidence interval [CI], 2.52–14.18 and adjusted OR, 4.97; 95% CI, 2.14–12.04) and complete MH (adjusted OR, 4.03; 95% CI, 1.56–11.51 and adjusted OR, 5.22; 95% CI, 1.97–14.89), respectively after adjustment for confounding factors (P for trend=0.001). Only in the low C-reactive protein (CRP) group (≤0.1 mg/dL), very high AGR was significantly positively correlated with complete MH but not CR (adjusted OR, 4.38; 95% CI, 1.06–21.77; P for trend=0.017). In the high CRP group, no correlation between AGR and complete MH was found.
Conclusion
Among Japanese patients with UC, AGR may be independently positively correlated with complete MH. In particular, among UC patients with low CRP, AGR might be a useful complementary marker for complete MH.
