J Korean Med Sci.  2023 Apr;38(14):e105. 10.3346/jkms.2023.38.e105.

Case 9: A 62-Year-Old Woman With Jaundice and General Weakness

• Cho HS
• Han JW
• Kim JH
• Nam H
• Sung PS
• Bae SH

• KMID: 2541545
• DOI: http://doi.org/10.3346/jkms.2023.38.e105

Figure

• 

  Fig. 1 Imaging findings at the hospitalization. (A) Non-contrast phase imaging of computed tomography showing high density of the liver (B) T2-weighted imaging of magnetic resonance imaging showing the low signal intensity of the liver.

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  Fig. 2 Histologic findings obtained from the initial liver biopsy. For the confirmation of diagnosis, liver biopsy was performed. (A-C) Histological findings of the initial liver biopsy. Hematoxylin and eosin stain was done. ×20 (left) and ×100 (right) slides showing severe lobular, portal, and periportal inflammation with hepatocyte necrosis (A). ×400 slide shows a red granule (arrowhead) among the necrotic cells. Ballooned hepatocytes and Mallory bodies are seen. (black narrow arrows) (B) Electron microscopy shows phospholipid laden lysosomal lamellar bodies (left, red arrow) and fatty deposition in the lysosome (right, blue arrow) (C).

• 

  Fig. 3 Serial laboratory findings from admission to 5 months after cessation of amiodarone. Serum levels of total bilirubin, AST, ALT, and γ-GTP at admission and 1 week, 1 month, 3 months, 5 months after the cessation of amiodarone are presented.γ-GTP = γ-glutamyl transpeptidase, ALT = alanine aminotransferase, AST = aspartate aminotransferase, Bx = biopsy, D/C = discharge, F/U = follow up.

• 

  Fig. 4 Histologic findings obtained from liver biopsy 5 month after amiodarone withdrawal. H&E stain was done. ×20 (left) and ×100 (right) slides H&E staining from the liver biopsy samples at 5 months after the cessation of amiodarone showing significant recovery from the liver injury.H&E = hematoxylin and eosin.

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