Blood Res.  2023 Mar;58(1):77-79. 10.5045/br.2023.2022200.

Lupus anticoagulant hypoprothrombinemia syndrome -could it be a sequelae of COVID-19?

• Stjepovic NM
• Kranjcec I
• Gagro A
• Jakovljevic G

• KMID: 2541068
• DOI: http://doi.org/10.5045/br.2023.2022200

Figure

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  Fig. 1 A large hematoma in the sacral area.

Reference

1. Rapaport SI, Ames SB, Duvall BJ. 1960; A plasma coagulation defect in systemic lupus erythematosus arising from hypoprothrombinemia combined with antiprothrombinase activity. Blood. 15:212–27. DOI: 10.1182/blood.V15.2.212.212. PMID: 14436248.

2. Kim JS, Kim MJ, Bae EY, Jeong DC. 2014; Pulmonary hemorrhage in pediatric lupus anticoagulant hypoprothrombinemia syndrome. Korean J Pediatr. 57:202–5. DOI: 10.3345/kjp.2014.57.4.202. PMID: 24868219. PMCID: PMC4030123. PMID: 364f9c68e02543d4afac7ebfda6975b1.

3. Mazodier K, Arnaud L, Mathian A, et al. 2012; Lupus anticoagulant- hypoprothrombinemia syndrome: report of 8 cases and review of the literature. Medicine (Baltimore). 91:251–60. DOI: 10.1097/MD.0b013e31826b971f. PMID: 22932789.

4. Komvilaisak P, Wisanuyotin S, Jettrisuparb A, Wiangnon S. 2017; Lupus anticoagulant-hypoprothrombinemia syndrome (LAC-HPS) in children with systemic lupus erythematosus: report of 3 cases. J Pediatr Hematol Oncol. 39:e521–4. DOI: 10.1097/MPH.0000000000000891. PMID: 28787393.

5. Yacobovich JR, Uziel Y, Friedman Z, Radnay J, Wolach B. 2001; Diffuse muscular haemorrhage as presenting sign of juvenile systemic lupus erythematosus and lupus anticoagulant hypoprothrom-binaemia syndrome. Rheumatology (Oxford). 40:585–7. DOI: 10.1093/rheumatology/40.5.585. PMID: 11371671.

6. Sakamoto A, Ogura M, Hattori A, et al. 2021; Lupus anticoagulant hypoprothrombinemia syndrome associated with bilateral adrenal haemorrhage in a child: early diagnosis and intervention. Thromb J. 19:19. DOI: 10.1186/s12959-021-00271-0. PMID: 33731125. PMCID: PMC7968225. PMID: 49fdf6c8e3a445758245d4ec2c434d59.

7. Jaeger U, Kapiotis S, Pabinger I, Puchhammer E, Kyrle PA, Lechner K. 1993; Transient lupus anticoagulant associated with hypoprothrombinemia and factor XII deficiency following adenovirus infection. Ann Hematol. 67:95–9. DOI: 10.1007/BF01788133. PMID: 8394145.

8. Appert-Flory A, Fischer F, Amiral J, Monpoux F. 2010; Lupus anticoagulant-hypoprothrombinemia syndrome (HLAS): report of one case in a familial infectious context. Thromb Res. 126:e139–40. DOI: 10.1016/j.thromres.2009.11.025. PMID: 20006899.

9. Schmugge M, Tölle S, Marbet GA, Laroche P, Meili EO. 2001; Gingival bleeding, epistaxis and haematoma three days after gastroenteritis: the haemorrhagic lupus anticoagulant syndrome. Eur J Pediatr. 160:43–6. DOI: 10.1007/PL00008415. PMID: 11195017.

10. Baca V, Montiel G, Meillón L, et al. 2002; Diagnosis of lupus anticoagulant in the lupus anticoagulant-hypoprothrombinemia syndrome: report of two cases and review of the literature. Am J Hematol. 71:200–7. DOI: 10.1002/ajh.10194. PMID: 12410576.

11. Bajaj SP, Rapaport SI, Fierer DS, Herbst KD, Schwartz DB. 1983; A mechanism for the hypoprothrombinemia of the acquired hypoprothrombinemia-lupus anticoagulant syndrome. Blood. 61:684–92. DOI: 10.1182/blood.V61.4.684.684. PMID: 6403077.

12. Becton DL, Stine KC. 1997; Transient lupus anticoagulants associated with hemorrhage rather than thrombosis: the hemorrhagic lupus anticoagulant syndrome. J Pediatr. 130:998–1000. DOI: 10.1016/S0022-3476(97)70291-9. PMID: 9202627.

13. Bowles L, Platton S, Yartey N, et al. 2020; Lupus anticoagulant and abnormal coagulation tests in patients with Covid-19. N Engl J Med. 383:288–90. DOI: 10.1056/NEJMc2013656. PMID: 32369280. PMCID: PMC7217555.